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MetabolomicsArsenic induces metabolome remodeling in mature human adipocytes
Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...
2025-05-23 | MTBLS8808 | MetaboLights
MetabolomicsGut Microbiome and Metabolome Alterations in Mice with Arsenic Exposure and Antibiotic Treatment: Potential Role of Arsenic Biotransformation Genes

Arsenic is the most prevalent toxic metalloid in environment. Evidence of mouse models (germ-free or antibiotic treatment) indicates the gut microbiota’s involvement in the metabolism of ingested arsenic. Linking genes to gut microbial arsenic metabolism with altered toxicity and lifetime in the ...

2025-05-12 | MTBLS11508 | MetaboLights
MetabolomicsMulti-omics reveals the response and adaptation of Acidithiobacillus ferrooxidans BY-3 under arsenic stress
Acidithiobacillus ferrooxidans exhibits arsenic resistance and plays a significant role in biometallurgy and sulfur cycling within ecosystems. This study employed integrated transcriptomic, proteomic, and metabolomic analyses to investigate the molecular response mechanisms of Acidithiobacillus ferr...
2026-09-03 | MTBLS15537 | MetaboLights
MetabolomicsArsenic-induced enhancement of diazotrophic recruitment and nitrogen fixation in Pteris vittata rhizosphere
Heavy metal contamination poses an escalating global challenge to soil ecosystems. Hyperaccumulators play a crucial role in environmental remediation and resource recovery. The enrichment of diazotrophs and resulting nitrogen accumulation promoted hyperaccumulator growth and facilitated phytoremedia...
2024-11-01 | MTBLS11419 | MetaboLights
TranscriptomicsAberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide
The purpose of this study is to search for aberrant genes in HaCaT keratinocytes after chronic exposure to arsenic trioxide. The objective of the investigation was to discover the mechanism of arsenic carcinogenicity in human epidermal keratinocytes. We hypothesize that a combined strategy of DNA mi...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37192 | biostudies-arrayexpress
ProteomicsFremont et al 2023 - Arsenic stress triggers active exudation of arsenic-phytochelatin complexes from Lupinus albus roots
Arsenic stress triggers active exudation of arsenic-phytochelatin complexes from Lupinus albus roots
ORGANISM(S): Lupinus Albus (ncbitaxon:3870) 
2023-10-10 | MSV000093078 | MassIVE
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
TranscriptomicsPrenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis
Developmental exposures play a role in adult onset chronic disease. The mechanisms by which environmental toxicants alter developmental processes predisposing individuals to chronic disease are not understood. arsenic exposure via drinking water causes cancer and cardiovascular disease. Transplacent...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-30783 | biostudies-arrayexpress
MetabolomicsMetabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, Islets (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001314 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice
Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of tBHQ or arsenic treatment given alone.
ORGANISM(S): Mus musculus 
2005-12-08 | E-MEXP-371 | biostudies-arrayexpress
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