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TranscriptomicsAberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide
The purpose of this study is to search for aberrant genes in HaCaT keratinocytes after chronic exposure to arsenic trioxide. The objective of the investigation was to discover the mechanism of arsenic carcinogenicity in human epidermal keratinocytes. We hypothesize that a combined strategy of DNA mi...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U266, MM.1s, KMS11, 8226/S multiple myeloma cell lines treated with arsenic
We used microarrays to examine changes in gene expression in multiple myeloma cell lines following treatment with arsenic trioxide and darinaparsin Experiment Overall Design: Four multiple myeloma cell lines (U266, MM.1s, KMS11, 8226/S) were treated with either arsenic trioxide (ATO) for 6, 24, or 4...
ORGANISM(S): Homo sapiens 
2009-02-01 | E-GEOD-14519 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of wheat seedlings following treatment with ultra-high diluted Arsenicum trioxide
A recently developed plant model [Betti et al., 2010 TheScientificWorldJOURNAL, 10, 2330M-^V2347] was used for identifying differentially expressed genes associated with plant response to ultra-high diluted (beyond the Avogadro limit) treatments. Seeds of common wheat (Triticum aestivum L.), previou...
ORGANISM(S): Triticum aestivum 
2015-03-12 | E-MEXP-3666 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis for HepG2 cells exposed to arsenic trioxide
DNA microarray analysis revealed that the genes related to cell cycle regulation were significantly induced at non- and sub-lethal concentrations (i.e., 0.05-6 M-BM-5M), while the common feature of heavy metal toxicity such as oxidative damage and following increase in glutathione, heat shock protei...
ORGANISM(S): Homo sapiens 
2013-07-02 | E-GEOD-48441 | biostudies-arrayexpress
TranscriptomicsWhole genome expression profile of lung epithelial cells following chronic arsenic exposure
This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide in vitro to elucidate cancer promoting gene signaling networks (GSNs) associated with As-transformed (B-As) cells. Following a six month exposure, exposed cells were assessed for enhanced cell proliferat...
ORGANISM(S): Homo sapiens 
2012-09-26 | E-GEOD-33520 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice
Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of tBHQ or arsenic treatment given alone.
ORGANISM(S): Mus musculus 
2005-12-08 | E-MEXP-371 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile of naive versus arsenic trioxide resistant acute promyelocytic leukemia cell line NB4
The aim of this study was to gain insight into the potential mechanism of resistance to arsenic trioxide (ATO). The gene expression profile of naive (NB4) (Acute promyelocytic leukemia (APL) cell line and one of its in house generated ATO resistant sub clone (NB4-VM-AsR1) was done using whole genome...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-42031 | biostudies-arrayexpress
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1537-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080730 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP772-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080736 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of untreated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080737 | MassIVE
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