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MetabolomicsMicrobiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Regional structure of the intestinal epithelium is critical for its function and is associated with the risk of specific gut diseases. However, how regionalization is established and how it influences disease susceptibility remains poorly understood. Here, we investigated the role of the gut micr...

2026-03-27 | MTBLS12063 | MetaboLights
ProteomicsIdentification of proteins exhibiting TgDegP2-responsive thermal stability
To broadly explore artemisinin susceptibility in apicomplexan parasites, we used genome-scale CRISPR screens recently developed for Toxoplasma gondii to discover sensitizing and desensitizing mutations. From these screens, we identified the mitochondrial protease DegP2, which appeared gDegP2-respons...
ORGANISM(S): Toxoplasma gondii GT1 
2020-08-28 | PXD019917 | Pride
Thermal proteome profiling Toxoplasma gondii Cetsa Artemisinin susceptibility 
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [CGH]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44128 | biostudies-arrayexpress
GenomicsGenome-Wide CRISPR Screens for Toxoplasma Gondii Genes Related to Artemisinin Susceptibility
Genome-Wide CRISPR Screens for Toxoplasma Gondii Genes Related to Artemisinin Susceptibility
PRJNA644018 | ENA
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [expression]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44127 | biostudies-arrayexpress
UnknownTransient temperature fluctuations severely decrease P. falciparum susceptibility to artemisinin in vitro.
Not available
S-EPMC6312858 | biostudies-literature
UnknownReduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
Not available
S-EPMC3553720 | biostudies-literature
UnknownModification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro.
Not available
S-EPMC7187599 | biostudies-literature
UnknownKnockout of the peroxiredoxin 5 homologue PFAOP does not affect the artemisinin susceptibility of Plasmodium falciparum.
Not available
S-EPMC5493673 | biostudies-literature
UnknownGenetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum.
Not available
S-EPMC7793257 | biostudies-literature
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