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Recent transcription profiling studies have revealed an unanticipatedly large proportion of antisense transcription across eukaryotic and bacterial genomes. However, the extent and significance of antisense transcripts is controversial partly because experimental artifacts are suspected. Here, we pr...
ORGANISM(S): Saccharomyces cerevisiae 
Sampling time-dependent artifacts in single-cell genomics studies
This dataset presents proteomic analyses validating the spatial proteomics technology, NicheProt. NicheProt is a 3D optical microscopy–guided, photobleaching-mediated cell barcoding approach for isolating intact cell types from defined microanatomical niches. Here, we evaluate whether tissue cryopre...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-19 | PXD075811 | Pride
Leather artifacts hold significant historical and cultural value in human civilization. During long-term preservation, ancient relics, especially waterlogged leather artifacts, are susceptible to protein degradation. Therefore, analyses of the structure and protein composition of these ancient relic...
ORGANISM(S): Bos Taurus 
2025-03-10 | PXD061671 |
Genomics
Soil samples near metal artifacts
This dataset contains proteomic analyses that validate the spatial proteomics technology, NicheProt. NicheProt is a 3D optical microscopy–guided, photobleaching-mediated cell barcoding approach designed to isolate intact cell types from specific microanatomical niches. We evaluate the proteomic prof...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-19 | PXD075769 | Pride
Single-cell RNA sequencing (scRNA-seq) is revolutionizing neuroimmune research, yet a critical bottleneck persists: the dissociation process introduces pervasive stress-altered transcription (SAT) that obscures genuine in vivo biology. Here, we present a comprehensive two-pronged strategy to elimina...
ORGANISM(S): Mus musculus 
2026-06-14 | GSE294852 | GEO
Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample acquisition can hinder solid, reproducible results and a systematic benchmarking is require...
ORGANISM(S): Homo sapiens 
2020-04-27 | GSE132065 | GEO
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