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GenomicsThe ASC-1 complex promotes translation initiation of the scanning ribosomes
The ASC-1 complex promotes translation initiation of the scanning ribosomes
PRJNA774189 | ENA
TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
UnknownCryo-EM structure of the human Asc-1 transporter complex.
Not available
S-EPMC11001984 | biostudies-literature
UnknownThe ASC-1 Complex Disassembles Collided Ribosomes.
Not available
S-EPMC7447978 | biostudies-literature
TranscriptomicsThe ASC-1 complex promotes translation initiation of the scanning ribosomes
Translation is initiated by binding of the eIF4F complex to the 5' cap of the mRNA, which is followed by scanning of the initiation codon by scanning ribosomes. Here we demonstrate that the ASC-1 complex (ASCC), which was previously shown to promote the dissociation of colliding 80S ribosomes, assoc...
ORGANISM(S): Homo sapiens 
2023-03-31 | GSE186502 | GEO
UnknownThe neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.
Not available
S-EPMC6294556 | biostudies-literature
TranscriptomicsUSR_template_replicates
Next-generation sequencing (NGS) of antibody variable regions has emerged as a powerful tool in systems immunology by providing quantitative molecular information on polyclonal humoral immune responses. Reproducible and robust information on antibody repertoires is valuable for basic and applied imm...
ORGANISM(S): Mus musculus 
2013-10-26 | E-MTAB-1896 | biostudies-arrayexpress
Genomics
SNORD50A/B disassemble ASC-1 complex to silence NF-kB and boost PD-1 blockade in non-small-cell lung cancer
PRJNA1428180 | ENA
TranscriptomicsASC controls T-bet-dependent CTL differentiation and defines transplant outcome independent of the inflammasome
The adaptor protein ASC is known to facilitate caspase-1 activation essential for innate host immunity via the formation of the inflammasome complex - a multi-protein structure responsible for processing IL-1beta and IL-18 to their active moieties. Here we demonstrate that ASC-deficient CD8+ T cell...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-78755 | biostudies-arrayexpress
UnknownAnti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.
Not available
S-EPMC3203143 | biostudies-literature
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