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To determine the global effects of ASCT2 inhibition, we used next generation sequencing to determine mRNA expression changes in PC-3 cells treated with BenSer or GPNA for 48 h. Examination of two different ASCT2 inhibitors BenSer and GPNA in prostate cancer cell line PC-3.
ORGANISM(S): Homo sapiens 
ASCT2 is a major contributor to serine uptake in cancer cells
The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse biosynthetic functions. While some tumors can synthesize serine de novo, others are auxotrophic and therefore reliant on serine uptake. Importantly, despite several transporters being known to be capable o...
ORGANISM(S): Homo sapiens 
2024-06-11 | GSE269606 | GEO
To determine the global effects of ASCT2 inhibition, we used next generation sequencing to determine mRNA expression changes in PC-3 cells treated with BenSer or GPNA for 48 h.
ORGANISM(S): Homo sapiens 
2015-04-10 | GSE65112 | GEO
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