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UnknownRecent origin and spread of a common Lithuanian mutation, G197del LDLR, causing familial hypercholesterolemia: positive selection is not always necessary to account for disease incidence among Ashkenazi Jews.
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S-EPMC1226098 | biostudies-literature
ProteomicsIRF4 mediates nonenzymatic dependency on IRE1 in Multiple 1 Myeloma cells
Multiple Myeloma (MM) arises through oncogenic transformation of immunoglobulin-secreting plasma cells. MM often co-opts the endoplasmic-reticulum (ER) stress mitigator, inositol requiring enzyme 1 (IRE1), to sustain malignant growth. While certain MMs require enzymatic IRE1-dependent activation of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095907 | MassIVE
ProteomicsATF6 promotes colorectal cancer growth and stemness by regulating the Wnt pathway
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) homeostasis by sensing protein-folding stress and orchestrating cellular adaptation via the ER-transmembrane proteins IRE1, PERK and ATF6. Malignant cells can co-opt UPR signaling by IRE1 and PERK to sustain tumor growth; howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095581 | MassIVE
ProteomicsleA nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
Endoplasmic-reticulum resident inositol-requiring enzyme 1alpha(IRE1) supports protein homeostasis via a cytoplasmic kinase-RNase module. Known cancer dependency on IRE1 entails its enzymatic activation of the transcription factor XBP1s and of RNA decay. We discovered that some cancer cells require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-22 | MSV000093902 | MassIVE
ProteomicsAnania et al. 2015. Caspase substrate profiling
raw mass spec data set associated with Anania et al. manuscript
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000079302 | MassIVE
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