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ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
ProteomicsFIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH) confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification hav...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080695 | MassIVE
UnknownStructural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome.
Not available
S-EPMC12816917 | biostudies-literature
UnknownAspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.
Not available
S-EPMC7251097 | biostudies-literature
UnknownSynthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase.
Not available
S-EPMC7383925 | biostudies-literature
UnknownSmall-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.
Not available
S-EPMC7588595 | biostudies-literature
UnknownKinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing.
Not available
S-EPMC7278358 | biostudies-literature
UnknownSynthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase.
Not available
S-EPMC8179049 | biostudies-literature
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
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