Sort   by:  
 Page size 
MetabolomicsAspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis...

2020-05-01 | MTBLS1559 | MetaboLights
MetabolomicsAspSnFR: A Genetically-Encoded Biosensor for Real-Time Monitoring of Aspartate in Live Cells

Aspartate is crucial for nucleotide synthesis, ammonia detoxification and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate concentrations in real time and in live cells. We intr...

2024-08-27 | MTBLS10035 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsAspartate potentiates tobramycin against multidrug-resistant Edwardsiella tarda through enhancing proton motive force and membrane permeability

The antibiotic susceptibility/resistance of bacteria is influenced by their metabolic states. In tobramycin-resistant Edwardsiella tarda (LTB4-RToB), a dynamic metabolic state is observed, characterized by a general reduction in most metabolites as the minimum inhibitory concentration (MIC) incre...

2025-07-31 | MTBLS12725 | MetaboLights
MetabolomicsMetabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor...
2018-12-04 | MTBLS789 | MetaboLights
MetabolomicsNoxa regulation of malate aspartate shuttle
Not available
ORGANISM(S): Homo sapiens 
ST000146 | MetabolomicsWorkbench
MetabolomicsUse of Aspartate Dehydrogenase by cancer cells
Not available
ORGANISM(S): Homo sapiens 
ST000154 | MetabolomicsWorkbench
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
MetabolomicsGlutaminolysis contribution to the carbon backbone of aspartate and glutamate in ccRCC
Not available
ORGANISM(S): Homo sapiens 
ST002222 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of C. necator H16 ΔmmsA123 ΔphaCAB cells grown with and without supplementation of aspartate
C. necator H16 can grow on aspartate as the sole carbon source. Using RNA-seq analysis here, we tried to identify genes that are overexpressed when the culture medium is supplemented with aspartate.
ORGANISM(S): Cupriavidus necator H16 
2022-11-21 | E-MTAB-11897 | biostudies-arrayexpress
Sort   by:  
 Page size