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GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52499 | biostudies-arrayexpress
TranscriptomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60131 | biostudies-arrayexpress
TranscriptomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [array]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52497 | biostudies-arrayexpress
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [ChIP-Seq]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52496 | biostudies-arrayexpress
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
TranscriptomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [RNA-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-54478 | biostudies-arrayexpress
GenomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [ChIP-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60130 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
UnknownFusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia.
Not available
S-EPMC11875166 | biostudies-literature
UnknownA FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.
Not available
S-EPMC5606002 | biostudies-literature
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