Sort   by:  
 Page size 
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52499 | biostudies-arrayexpress
TranscriptomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60131 | biostudies-arrayexpress
TranscriptomicsCell stage dependent transcriptional response to leukemic oncogene
Acute myeloid leukemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation which gives rise to the RUNX1/ETO fusion pr...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-64541 | biostudies-arrayexpress
GenomicsCell stage dependent transcriptional response to leukaemic oncogene expression
Acute myeloid leukemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation which gives rise to the RUNX1/ETO fusion pr...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-64589 | biostudies-arrayexpress
TranscriptomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [array]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52497 | biostudies-arrayexpress
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [ChIP-Seq]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52496 | biostudies-arrayexpress
TranscriptomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [RNA-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-54478 | biostudies-arrayexpress
GenomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [ChIP-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60130 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
Sort   by:  
 Page size