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GenomicsSF3B1 association with chromatin determines splicing outcomes
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. Part of the explanation probably lies in differences in chromatin organization between exons and introns. Pro...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-65644 | biostudies-arrayexpress
TranscriptomicsHP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can act both as an enhancer and as a silencer of splicing, and affects the splicing of more than 20...
ORGANISM(S): Mus musculus 
2015-03-08 | E-GEOD-64910 | biostudies-arrayexpress
UnknownSustained uremic toxin control improves renal and cardiovascular outcomes in patients with advanced renal dysfunction: post-hoc analysis of the Kremezin Study against renal disease progression in Korea.
Not available
S-EPMC5331977 | biostudies-literature
UnknownR. verniciflua and E. ulmoides Extract (ILF-RE) Protects against Chronic CCl₄-Induced Liver Damage by Enhancing Antioxidation.
Not available
S-EPMC6412399 | biostudies-literature
UnknownImpact of Clinical and Lesion Features on Outcomes After Percutaneous Coronary Intervention in Bifurcation Lesions.
Not available
S-EPMC9743454 | biostudies-literature
TranscriptomicsStrategies for in vivo screening and mitigation of hepatotoxicity associated with antisense drugs
In this study we tested and modeled the hepatotoxic potential of locked nucleic acid-containing phosphorothioated antisense oligonucleotide (ASOs) gapmers designed to target human BACH1 and PAR-2 transcripts. Using RNA extracted from mouse livers we compared expression profiles of off-target (i.e. g...
ORGANISM(S): Mus musculus 
2017-08-02 | E-MTAB-5180 | biostudies-arrayexpress
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
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