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MetabolomicsATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth

Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here, we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferring diacylglycerol (DAG), and potentially triacylglycerol ...

2025-09-07 | MTBLS12951 | MetaboLights
MetabolomicsMetabolomic profiling of primary mouse proximal tubule cells (mPTCs) derived from 24-week-old CTR and Atg7 PT-KO kidneys
To explore the role of ATG7 in the kidney PT, we crossed mice homozygous for floxed alleles of Atg7 with Ggt1-Cre mice expressing Cre recombinase under the rat Ggt1 (gamma-glutamyltransferase 1) gene promoter. This generated Atg7fl/fl; γGt1cre/cre mice (hereafter referred to as Atg7 PT-KO), in which...
2026-09-30 | MTBLS15857 | MetaboLights
MetabolomicsHigh-resolution LC-MS/MS lipidomics characterization of wild-type and ATG7-deficient mouse renal proximal tubule cells
This study provides an untargeted lipidomics investigation of ATG7-deficient (cKO) mouse renal proximal tubule cells compared to wild-type (WT) controls to evaluate lipidomic alterations associated with autophagy deficiency. Lipids were extracted from cell culture wells using a single-phase isopropa...
2026-09-30 | MTBLS15861 | MetaboLights
MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
UnknownA fluorescent tool set for yeast Atg proteins.
Not available
S-EPMC4502664 | biostudies-literature
UnknownCrystallographic Characterization of ATG Proteins and Their Interacting Partners.
Not available
S-EPMC5429400 | biostudies-literature
GenomicsATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
ATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
PRJNA1279070 | ENA
TranscriptomicsATG-9-Mediated Synaptic Autophagy Promotes Aversive Learning under Stress in C. elegans
Autophagy is a degradative process that maintains cellular homeostasis and functions. Autophagy biogenesis at neuronal synapses requires synaptic proteins, but its impact on synaptic functions is incompletely understood. Here we show that, in Caenorhabditis elegans, synaptic ATG-9, the only transmem...
ORGANISM(S): Caenorhabditis elegans 
2026-05-21 | GSE300122 | GEO
GenomicsATG conjugation system -dependent and -independent mechanisms underlie lysosomal stress-induced TFEB regulation
ATG conjugation system -dependent and -independent mechanisms underlie lysosomal stress-induced TFEB regulation
PRJNA985714 | ENA
UnknownAutophagy signal transduction by ATG proteins: from hierarchies to networks.
Not available
S-EPMC4648967 | biostudies-literature
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