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ProteomicsAtg7–Atg12 conjugation and autophagy are negatively regulated by the disordered region of Atg12
: The macroautophagy/autophagy machinery has two ubiquitin-like (UBL) conjugation systems. The Atg8/MAP1LC3/GABARAP (yeast/human) and Atg12/ATG12 proteins are UBL substrates for Atg7/ATG7, a non-canonical E1 enzyme, that thioesterifies its substrates; however, autophagy requires a much greater amoun...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-05-05 | PXD077491 | Pride
Atg3 Atg8 Atg10 Ubiquitin-like 
GenomicsFunctional Characterisation of the Ubiquitin-like Core Autophagy Protein ATG12 in Dictyostelium discoideum
Functional Characterisation of the Ubiquitin-like Core Autophagy Protein ATG12 in Dictyostelium discoideum
PRJNA509858 | ENA
TranscriptomicsFunctional Characterisation of the Ubiquitin-like Core Autophagy Protein ATG12 in Dictyostelium discoideum
Purpose: First global survey of the transcriptome in autophagy-deficient strains of D. discoideum. Results: Our RNAseq analysis of ATG12‾, ATG16‾ and ATG12‾/16‾ cells revealed major transcriptional changes in a large number of genes in comparison to AX2. Conclusions: Our study represents the first d...
ORGANISM(S): Dictyostelium discoideum 
2019-01-15 | GSE123780 | GEO
UnknownThe Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Not available
S-EPMC1955809 | biostudies-literature
UnknownStructural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
Not available
S-EPMC3839761 | biostudies-literature
UnknownStructure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.
Not available
S-EPMC3540207 | biostudies-literature
UnknownStructure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation.
Not available
S-EPMC3596133 | biostudies-literature
UnknownFunctional Characterization of Ubiquitin-Like Core Autophagy Protein ATG12 in Dictyostelium discoideum.
Not available
S-EPMC6356199 | biostudies-literature
UnknownATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.
Not available
S-EPMC4344874 | biostudies-literature
UnknownOncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Not available
S-EPMC5846558 | biostudies-literature
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