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UnknownPGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.
Not available
S-EPMC4560688 | biostudies-literature
UnknownCharacterization of lipolytic inhibitor G(0)/G(1) switch gene-2 protein (G0S2) expression in male Sprague-Dawley rat skeletal muscle compared to relative content of adipose triglyceride lipase (ATGL) and comparitive gene identification-58 (CGI-58).
Not available
S-EPMC4374944 | biostudies-literature
TranscriptomicsLipid droplets modulate autophagy receptor SQST-1/SQSTM1 dynamics and lifespan
RNA-seq performed for studying transcriptomic changes modulated by ATGL-1
ORGANISM(S): Caenorhabditis elegans 
2022-12-31 | GSE204953 | GEO
TranscriptomicsLipolysis Engages CD36 to Promote ZBP1-Mediated Necrosis Impairing Lung Regeneration in COPD
Lung parenchyma destruction represents a severe condition commonly found in chronic obstructive pulmonary disease (COPD), the leading cause of morbidity and mortality worldwide. Promoting lung regeneration is crucial for achieving clinical improvement. However, no therapeutic drugs are approved to i...
ORGANISM(S): Mus musculus 
2024-12-13 | GSE246501 | GEO
TranscriptomicsSpatial transcriptomics of adipocyte-specific ATGL-KO mice 24 h after cardiac ischemia
We generated a tamoxifen-inducible, adipocyte-specific ATGL-KO animals to analyze the role of adipocyte ATGL in cardiac ischemia/reperfusion. KO was induced in 10 weeks old male mice via 7d of consecutive i.p.-injections of 500µg hydroxytamoxifen/day. Pnpla2-flox homozygous, Cre-negative littermates...
ORGANISM(S): Mus musculus 
2026-02-28 | E-MTAB-12700 | biostudies-arrayexpress
TranscriptomicsCaspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity
Caspases are cysteine proteases that regulate programmed cell death. While caspase-6, an executioner caspase, is known for its role in neurodegeneration and cell death, its broader physiological functions remain poorly understood. Our previous study revealed that caspase-6 drives liver injury and fi...
ORGANISM(S): Mus musculus 
2026-04-22 | GSE311559 | GEO
UnknownATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Not available
S-EPMC3244833 | biostudies-literature
GenomicsLipid droplets modulate autophagy receptor SQST-1/SQSTM1 dynamics and lifespan
Lipid droplets modulate autophagy receptor SQST-1/SQSTM1 dynamics and lifespan
PRJNA842768 | ENA
UnknownMacrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice.
Not available
S-EPMC3063945 | biostudies-literature
GenomicsHypoxia coordinates adipocyte hypertrophy andhyperplasia through HlF1aa-ATGL-PPARy pathway enablesrapid and healthy energy storage in grass carp
Animals often face food scarcity in nature. In order to survive, some animals store substantial fat when food is available. However, the physiological mechanism by which they store substantial fat and maintain metabolic health in the short term is poorly understood. Here, using the grass carp (Cteno...
ORGANISM(S): Ctenopharyngodon idella 
2026-03-04 | GSE315218 | GEO
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