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TranscriptomicsA role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
Epigenetic silencing of transposons by Piwi-interacting RNAs (piRNAs) constitutes an RNA-based genome defense mechanism. Piwi endonuclease action amplifies the piRNA pool by generating new piRNAs from target transcripts by a poorly understood mechanism. Here, we identified mouse Fkbp6 as a factor in...
ORGANISM(S): Bombyx mori 
2012-09-04 | E-GEOD-39203 | biostudies-arrayexpress
ProteomicsSubstrate selectivity for semisynthetic CK2 proteins with Pin1
Protein Ser/Thr kinase CK2 is involved in a myriad of cellular processes including cell growth and proliferation by phosphorylating hundreds of substrates, yet the regulation process of CK2 function is poorly understood. The CK2 catalytic subunit, CK2α, is phosphorylated at Thr344 and phosphorylati...
ORGANISM(S): synthetic construct 
2011-10-24 | E-GEOD-33150 | biostudies-arrayexpress
ProteomicsDeciphering Staphylococcus aureus-host dynamics using dual Activity-based protein profiling of ATP-interacting proteins
This study focuses on ATP-binding proteins to dissect the complex interplay between Staphylococcus aureus and human cells, particularly macrophages (THP-1) and keratinocytes (HaCaT), during the course of an intracellular infection. A snapshot of the various protein activity and function is provided ...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2024-04-22 | PXD049003 | Pride
Atp-interacting proteins Thp-1 cell infection Staphylococcus aureus Activity-based protein profiling Hacat cel infectionl Host-pathogen interaction 
TranscriptomicsRNA clamping by Vasa assembles a piRNA Amplifier complex on transposon transcripts
Germline-specific Piwi-interacting RNAs (piRNAs) protect the genome against selfish genetic elements and are essential for fertility in animals. piRNAs targeting active transposons are amplified by a feed-forward loop known as the Ping-pong cycle, which links endonucleolytic slicing of target RNA...
ORGANISM(S): Bombyx mori 
2014-06-04 | E-GEOD-57420 | biostudies-arrayexpress
UnknownDeciphering Staphylococcus aureus-host dynamics using dual activity-based protein profiling of ATP-interacting proteins.
Not available
S-EPMC11097646 | biostudies-literature
UnknownProteins interacting with mitochondrial ATP-dependent Lon protease (MAP1) in Magnaporthe oryzae are involved in rice blast disease.
Not available
S-EPMC6638408 | biostudies-literature
TranscriptomicsDicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
Drosophila Dicer-1 produces microRNAs (miRNAs) from pre-miRNA, whereas Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. loquacious (loqs) encodes three Dicer partner proteins, Loqs-PA, Loqs-PB, and, Loqs-PD, generated by alternative splicing. To understand the function of each Loqs...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-37443 | biostudies-arrayexpress
TranscriptomicsNOT2 proteins promote Pol II-dependent transcription and interact with multiple miRNA biogenesis factors in Arabidopsis
MicroRNAs (miRNAs) play key regulatory roles in numerous developmental and physiological processes in animals and plants. The elaborate mechanism of miRNA biogenesis involves transcription and multiple processing steps. Here, we report the identification of a pair of evolutionarily conserved NOT2_3_...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-42901 | biostudies-arrayexpress
GenomicsIdentification and characterization of novel proteins associated with CHD4
Identification and characterization of novel proteins associated with CHD4
PRJNA786884 | ENA
ProteomicsComparative analysis of the human and mouse placental transcriptome and proteome
An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human to mouse. The human and mouse placenta show structural similarities but there have been no systematic attempt to assess their molecular...
ORGANISM(S): Mus musculus 
2009-06-29 | E-GEOD-13299 | biostudies-arrayexpress
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