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MetabolomicsTargeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study

Background. Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, carries a high risk of severe complications. Patients diagnosed with paroxysmal atrial fibrillation (PAF) may progress to persistent atrial fibrillation (PerAF) following a period. We aimed to identify metabo...

2026-07-03 | MTBLS13136 | MetaboLights
TranscriptomicsDevelopment of gene expression signatures for ANP in HUVEC
Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC...
ORGANISM(S): Homo sapiens 
2014-04-23 | E-GEOD-56976 | biostudies-arrayexpress
ProteomicsStructural characterization of atrial natriuretic peptide amyloid fibrils from patients with atrial fibrillation
Isolated atrial amyloidosis (IAA) is a localized cardiac disorder characterized by atrial natriuretic peptide (ANP) amyloids deposition in the atria, linked to aging and atrial fibrillation (AF). While monomeric ANP regulates blood pressure, its dimeric form is associated with cardiovascular conditi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD066795 | Pride
Peptidomics Nano lc-ms/ms Atrial natriuretic peptide Isolated atrial amyloidosis 
TranscriptomicsTranscription profiling of normal atria and ventricles
Pharmacological and gene ablation studies have demonstrated a crucial role of the cardiac natriuretic peptides (NP) hormones ANF and BNP in the maintenance of cardiovascular homeostasis. In addition, hypertension and chronic congestive heart failure are clinical entities that may be regarded as st...
ORGANISM(S): Rattus norvegicus 
2009-09-15 | E-GEOD-5266 | biostudies-arrayexpress
TranscriptomicsImpairment of cardiac natriuretic peptide signaling develops the excessive cardiac hypertrophy during lactation period
Two natriuretic peptides, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) act through the common receptor, guanylyl cyclase-A (GC-A) to lower blood pressure, induce diuresis/natriuresis and dilate blood vessels. Recently, we discovered that the excessive cardiac hypertrophy acco...
ORGANISM(S): Mus musculus 
2019-09-01 | GSE84744 | GEO
ClinicalAtrial Fibrillation After Surgery for Colorectal Cancer
This study will report the incidence of atrial fibrillation after elective colorectal cancer resection in the over 65 age group. This will be used to validate a risk model for the development of post-operative atrial fibrillation. Eligible patients will undergo electrocardiogram based screening for ...
2312263 | ecrin-mdr-crc
UnknownAtrial natriuretic peptide frameshift mutation in familial atrial fibrillation.
Not available
S-EPMC2518320 | biostudies-literature
TranscriptomicsIdentification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress
The paralogous genes Nppa and Nppb are organized in an evolutionary conserved cluster and are a valuable model to study coregulation and regulatory landscape organization during heart development and disease. Here, we analyzed the chromatin conformation, epigenetic status and enhancer potential of s...
ORGANISM(S): Mus musculus 
2016-07-02 | E-GEOD-81057 | biostudies-arrayexpress
GenomicsLoss of atrial natriuretic peptide signaling causes mitochondrial dysfunction, insulin resistance and low endurance capacity
Loss of atrial natriuretic peptide signaling causes mitochondrial dysfunction, insulin resistance and low endurance capacity
PRJNA1026859 | ENA
TranscriptomicsRNA-seq analysis of human heart failure
The goal of this study is to compare the transcriptome of heart failure patients (with ischemic or dilated cardiomyopathy) undergoing heart transplantation compared with healthy controls. We analyzed 36 human samples. 13 from ischemic and 13 from dilated human hearts compared with 10 healthy control...
ORGANISM(S): Homo sapiens 
2014-04-28 | E-GEOD-55296 | biostudies-arrayexpress
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