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ProteomicsProximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a role for spinophilin in protein regulation.
The major synaptic protein phosphatase 1 (PP1) targeting protein, spinophilin can inhibit or target PP1 activity towards diverse substrates. To detail the full panoply of substrates at which spinophilin modulates PP1 activity, we have validated a novel approach that permits proximity labeling and or...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-02 | MSV000096575 | MassIVE
UnknownThe overlapping burden of the three leading causes of disability and death in sub-Saharan African children.
Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these ...
S-EPMC9726883 | biostudies-literature
UnknownSubnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study.

Background

High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV ...
S-EPMC8187986 | biostudies-literature
UnknownMapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018.
Exclusive breastfeeding (EBF)-giving infants only breast-milk for the first 6 months of life-is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and p...
S-EPMC8373614 | biostudies-literature
UnknownMapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 20...
S-EPMC7220891 | biostudies-literature
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