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GenomicsGene Expression Profiles of Atxn3-WT and Atxn3-KO mouse embryonic fibroblasts
Gene Expression Profiles of Atxn3-WT and Atxn3-KO mouse embryonic fibroblasts
PRJNA480874 | ENA
TranscriptomicsGene Expression Profiles of Atxn3-WT and Atxn3-KO mouse embryonic fibroblasts
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene, which encodes a deubiquitinating enzyme, ATXN3, implicated in numerous quality control pathways. Several mechanisms have been proposed ...
ORGANISM(S): Mus musculus 
2018-07-13 | GSE117028 | GEO
UnknownATXN3 deubiquitinates YAP1 to promote tumor growth.
Not available
S-EPMC10560956 | biostudies-literature
GenomicsEstablishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3
Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3
PRJNA1425979 | ENA
UnknownEvaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse Models.
Not available
S-EPMC5415970 | biostudies-literature
UnknownATXN3 controls DNA replication and transcription by regulating chromatin structure.
Not available
S-EPMC10287915 | biostudies-literature
UnknownATXN3 deubiquitinates ZEB1 and facilitates epithelial-mesenchymal transition in glioblastoma.
Not available
S-EPMC11885642 | biostudies-literature
GenomicsEstablishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3 [Advil RNA-seq]
Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3 [Advil RNA-seq]
PRJNA1458652 | ENA
TranscriptomicsEstablishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded ATXN3
Objective Repeat expansion mutations underlie diverse neurogenetic disorders, many involving the peripheral nervous system. Despite peripheral neuropathy being the most common neurological disorder worldwide, its contribution to repeat expansion diseases remains poorly defined, and robust preclinica...
ORGANISM(S): Mus musculus 
2026-05-11 | GSE320015 | GEO
UnknownBiochemical analysis to study wild-type and polyglutamine-expanded ATXN3 species.
Not available
S-EPMC11666052 | biostudies-literature
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