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ProteomicsA systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination
Nucleosomes composed of histones are the fundamental units around which DNA is wrapped to form chromatin. Transcriptionally active euchromatin or repressive heterochromatin is regulated in part by the addition or removal of histone post-translational modifications (PTMs) by ‘writer’ and ‘eraser’ enz...
ORGANISM(S): Trypanosoma brucei 
2021-08-05 | PXD026743 | Pride
Proteomics Trypanosoma brucei Chromatin 
ProteomicsTEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piR...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-18 | PXD019087 | Pride
Mouse transposon silencing 
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