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TranscriptomicsCD8 CDKN2A-/- lymphocytes expressing an active form of the transcription factor Stat5
Transcriptome analyses of memory CDKN2A-/- CD8 T lymphocytes expressing an active form of the transcription factor Stat5. CDKN2A-/- CD8 T lymphocytes were activated by anti-CD3/CD28. After 40h, an active form of Stat5 was introduced in activated cells. Culture was continued for another 48h to indu...
ORGANISM(S): Mus musculus 
2015-05-04 | E-GEOD-56154 | biostudies-arrayexpress
TranscriptomicsActive STAT5 in CD8 T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41819 | biostudies-arrayexpress
GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of murine omental macrophages after inoculation with ovarian cancer cells
Single cell RNA sequencing of macrophages harvested from omentum of mice 10 weeks after intra peritoneal inoculation of epithelial ovarian cancer cells.
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8593 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of macrophages from normal and tumor-infiltrated omentum
Sequencing of mRNA from tissue-resident and tumor-associated macrophages in murine omentum display distinct transcriptional profile between macrophage subset of different origin
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8141 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of ID8 ovarian cancer cells after harvest from malignant ascites
Sequencing of mRNA from ID8 tumor cells and ID8 tumor cells harvested from ascites of mice 11 weeks after intra peritoneal inoculation show acquisition of cancer stem cell-like features in ascitic tumor cells.
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8140 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD8 T cells in response to P1A antigen expressing tumor cells or cells not expressing 1A antigen
Activation status of CD8 T cells in response to a tumor challenge. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma...
ORGANISM(S): Mus musculus 
2007-12-01 | E-MEXP-1285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NK cells in presence/absence of activated CD8 T cells
we compare NK cells in presence of activated CD8 T cells or not. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma t...
ORGANISM(S): Mus musculus 
2007-11-01 | E-MEXP-1284 | biostudies-arrayexpress
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