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TranscriptomicsThe investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in mouse bladder cancer cells in vitro and in vivo
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladde...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42089 | biostudies-arrayexpress
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
ProteomicsCmDnm1, in vitro phosphorylation by CmAUR, Gel
Recombinant Cyanidioschyzon Dnm1 protein (CmDnm1) was incubated with or without recombinant Cyanidioschyzon Aurora kinase (CmAUR). Proteins were separated by SDS-PAGE, in-gel tryptic digested, analyzed by LC-MS.
ORGANISM(S): Cellular Organisms 
2020-01-14 | PXD012329 | JPOST Repository
ProteomicsCmDnm1, in vitro phosphorylation by CmAUR
Recombinant Cyanidioschyzon Dnm1 protein (CmDnm1) was incubated with recombinant Cyanidioschyzon Aurora kinase (CmAUR). Proteins were tryptic digested and the phosphorylated peptides were concentrated with Titansphere Phos -TiO Kit. Finally, the enriched peptides were analyzed by LC-MS.
ORGANISM(S): Cyanidioschyzon Merolae 
2019-12-27 | PXD013717 | JPOST Repository
TranscriptomicsThe novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models
we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress
ProteomicsAurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.
Precise regulation of kinetochore-microtubules is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the N-terminal “tail” domain of Hec1/NDC80, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-28 | PXD006892 | Pride
Human aurora a kinase hec1 
ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
Proteomicspre-mRNA splicing is regulated by an Aurora-A-mediated phopsho-signaling network
In this study, we identified many new potential interactors of the Aurora-A kinase using a proteomic approach. A significant portion of Aurora-A interaction network is composed of proteins involved in pre-mRNA splicing, implying that Aurora-A signaling extends beyond its canonical function. Aurora-A...
ORGANISM(S): Homo sapiens (Human) 
2024-12-11 | PXD021093 | Pride
Aurora kinase Lc-ms/ms 
TranscriptomicsAurora kinase A is upregulated in cutaneous T-cell lymphoma and represents a potential therapeutic target
Cutaneous T-cell lymphomas form a heterogeneous group of non-Hodgkin lymphomas characterized by only poor prognosis in advanced stage. Despite significant progress made in the identification of novel genes and pathways involved in the pathogenesis of cutaneous lymphoma, the therapeutic value of thes...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-59307 | biostudies-arrayexpress
ProteomicsThe structural basis of the multi-step allosteric activation of Aurora B kinase
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the ...
ORGANISM(S): Xenopus cf. laevis UF 185698 
2023-05-31 | PXD038935 | Pride
Xenopus laevis Hdx-ms Aurora b 
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