Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occured in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans-side ...
In this study we adopt a chemical genetics system to evaluate whether auto-deubiquitylation would make DUBs poor substrates for targeted protein degradation.
Guisoni2016 - Cis-regulatory system (CRS) can
drive sustained oscillations
This model is described in the article:
Promoters Architecture-Based
Mechanism for Noise-Induced Oscillations in a Single-Gene
Circuit.
Guisoni N, Monteoliva D, Diambra
L.
PLoS ONE 2016; 11(3): e015...
Shimoni2009 - Escherichia Coli SOS
Simple model, involving only the basic components of the circuit, sufficient to explain the peaks in the promoter activities of recA and lexA.
This model is described in the article:
Stochastic...