Autoimmune arthritis

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Unknown (4088)
Transcriptomics (363)
Genomics (317)
Proteomics (67)
Genomic (16)
Other (10)
Methylation profiling (8)
Metabolomics (6)
Models (5)
Clinical (4)

Organisms

Homo sapiens (319)
Mus musculus (127)
Rattus norvegicus (14)
human gammaherpesvirus 4 (3)
unidentified (2)
Staphylococcus aureus (2)
Torque teno virus (2)
Human endogenous retrovirus K (2)
Caprine arthritis encephalitis virus (2)
Proteus mirabilis (2)
Betapolyomavirus macacae (2)
Human alphaherpesvirus 2 (2)
Human alphaherpesvirus 1 (2)
Klebsiella pneumoniae (2)
Human immunodeficiency virus 1 (2)
Human betaherpesvirus 5 (2)
Mycobacterium tuberculosis (2)
Streptococcus agalactiae (1)
Coxsackievirus A20 (1)
Coxsackievirus B4 (1)
Hepatitis C virus isolate HC-J6 (1)
Human poliovirus 3 strain Sabin (1)
Human herpesvirus 4 type 2 (1)
Coxsackievirus A9 (1)
Staphylococcus aureus A9635 (1)
Paraburkholderia fungorum (1)
Human rotavirus MP409 (1)
Prochlorococcus marinus str. MIT 9202 (1)
Human Endogenous Retrovirus IDDMK1,2-22 (1)
Human adenovirus 12 (1)

Organisms

Homo sapiens (138)
Mus musculus (65)
Rattus norvegicus (3)
human gut metagenome (2)
human nasopharyngeal metagenome (1)
rat gut metagenome (1)
Canis lupus familiaris (1)
human oral metagenome (1)
mouse metagenome (1)
gut metagenome (1)
mouse gut metagenome (1)
Bos taurus (1)

Repository

ENA (274)
biostudies-arrayexpress (239)
geo (186)
pride (39)
dbGaP (16)
EGA (15)
iProX (9)
MetaboLights (6)
BioModels (5)
MassIVE (3)

Tissue

Blood serum (9)
Cell culture (5)
Spleen (5)
B cell (3)
Blood (3)
T cell (3)
Blood plasma (2)
Macrophage (2)
Primary cell (2)
Synovial fluid (2)
Synovial tissue (2)
T-lymphocyte (2)
B-lymphocyte (1)
Blood cell (1)
Brain (1)
Colon sigmoideum (1)
Colonic mucosa (1)
Dendritic cell (1)
Epithelial cell (1)
Gray matter (1)
JURKAT cell (1)
Kidney (1)
Layer of synovial tissue (1)
Lymph node (1)
Permanent cell line cell (1)
Synovium (1)
White matter (1)

Disease

Rheumatoid arthritis (16)
Rheumatoid Arthritis (1)
Primary osteoarthritis (1)
Acute monoblastic leukaemia (1)
Serum transferred arthritis (1)
Normal (1)
Cataract (1)
Psoriatic arthritis (1)
Melanoma (1)
Neoplasms (1)
Acute leukemia (1)
Arthritis (1)
Disease free (1)
Lymphoma (1)
Multiple sclerosis (1)
Myasthenia gravis (1)

Technology Type

Mass Spectrometry (39)
Shotgun proteomics (21)
Gel-based experiment (7)
Affymetrix 500K, unknown (4)
Bottom-up proteomics (4)
Mass spectrometry assay (3)
Affinity purification coupled with mass spectrometry proteomics (3)
Data-dependent acquisition (3)
Unknown, Affymetrix 500K (2)
Top-down proteomics (2)
Illumina Genome Analyzer II (1)
NMR spectroscopy assay (1)
NMR spectroscopy (1)
Mass spectrometry (1)
Data-independent acquisition (1)
MSE (1)

Instrument Platform

Illumina HiSeq 2500 (7)
Illumina HiSeq 4000 (7)
NextSeq 500 (7)
Illumina NovaSeq 6000 (4)
Illumina HiSeq 1500 (2)
Q Exactive (2)
Nuclear Magnetic Resonance (NMR) - (2)
Liquid Chromatography MS - negative - HILIC (2)
Liquid Chromatography MS - positive - HILIC (2)
See Description (1)
See Desciption (1)
Manual labeling (1)
Manual extraction (1)
Clinical procedure using endoscopic equimpent (1)
10x machine (1)
Dell T8310 (1)
Agilent SureScan High-Resolution DNA Microarray Scanner (1)
IScan (1)
Spectronic Helios Alpha UV-Vis spectrophotometer (1)
Bioanalyser (1)
Axon- GenePix4000B (1)
Illumina Genome Analyzer II (1)
Illumina NovaSeq X (1)
DNBSEQ-G400 (1)
DNBSEQ-T7 (1)
Illumina HiSeq 2000 (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion Lumos (1)
6490 Triple Quadrupole LC/MS (Agilent) (1)
Liquid Chromatography MS - alternating - reverse-phase (1)

Publication Date

2025 (37)
2014 (36)
2023 (34)
2012 (34)
2026 (33)
2015 (33)
2024 (28)
2010 (25)
2022 (23)
2020 (23)
2013 (22)
2008 (22)
2009 (20)
2011 (19)
2019 (18)
2016 (18)
2017 (17)
2021 (16)
2018 (15)
2007 (6)
2005 (5)
2004 (2)
2006 (1)

CHEBI ID

CHEBI:72785 (1)
CHEBI:68947 (1)
CHEBI:88345 (1)
CHEBI:63977 (1)
CHEBI:88346 (1)
CHEBI:72866 (1)
CHEBI:63976 (1)
CHEBI:72815 (1)
CHEBI:72786 (1)
CHEBI:34499 (1)
CHEBI:72843 (1)
CHEBI:34506 (1)
CHEBI:72665 (1)
CHEBI:63966 (1)
CHEBI:38299 (1)
CHEBI:34494 (1)
CHEBI:72657 (1)
CHEBI:72651 (1)
CHEBI:72647 (1)
CHEBI:19138 (1)
CHEBI:72640 (1)
CHEBI:72643 (1)
CHEBI:72639 (1)
CHEBI:72637 (1)
CHEBI:64017 (1)
CHEBI:60943 (1)
CHEBI:72608 (1)
CHEBI:72606 (1)
CHEBI:15553 (1)
CHEBI:28158 (1)

Metabolite Name

5a-Androst-3-en-17-one (2)
Octadecyl fumarate (2)
Behenic acid (2)
27-Norcholestanehexol (2)
PC(16:0/20:5(5Z,8Z,11Z,14Z,17Z)) (2)
5,10-Pentadecadien-1-ol (2)
11-Hydroxy-9-tridecenoic acid (2)
Acetyl-CoA (2)
PC(O-16:1(9Z)/20:0) (2)
PC(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (2)
PA(16:1(9Z)/22:2(13Z,16Z)) (2)
Panaxatriol (2)
Linoleamide (2)
Stearoylcarnitine (2)
SM(d18:1/14:0) (2)
14,15-DiHETrE (2)
13-HODE (2)
Hydroxypropionylcarnitine (2)
L-Lysine (2)
L-Proline (2)
Ornithine (2)
2-Methylbutyroylcarnitine (2)
L-Asparagine (2)
L-Threonine (2)
Androsterone (2)
Methyl jasmonate (2)
L-Histidine (2)
Palmitoylcarnitine (2)
Sorbitan laurate (2)
Creatine (2)

First Public Date

2025 (39)
2026 (36)
2014 (35)
2023 (31)
2024 (26)
2022 (21)
2018 (17)
2021 (16)
2020 (14)
2019 (14)
2017 (9)
2015 (7)
2016 (6)
2013 (3)

Modelling Approach

Constraint-based model (4)
Boolean model (1)

Study status

Recruiting (4)

Lab affiliation

Division of Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Sweden (4)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n 18016, Granada-Spain (2)
Aalborg University, Denmark (1)
Analytical Chemistry Department, University of Barcelona (1)
Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand (1)
Chief, Division of Immunology, Boston Children’s Hospital Professor of Pediatrics and Medicine (1)
Clinical and Diagnostic Immunology, Department Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium (1)
Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China (1)
Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Canada; Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Canada (1)
Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil (1)
Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands (1)
Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands. (1)
Discovery Proteomics Facility Oxford (1)
Disease Biology Lab School of Biotechnology, Campus 11 KIIT Deemed to be University Bhubaneswar Odisha (1)
Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute, Sweden The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), 710004, Xi'an, China (1)
Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Sweden (1)
Division of chemistry I, Department of Medical Biochemistry & Biophysics, Karolinska Institutet (1)
IIBB-CSIC, Spain (1)
Institute for Microbiology Department of Microbial Proteomics and Mass Spectrometry Ernst-Moritz-Arndt-University Greifswald F.-L.-Jahn-Str. 15 17489 Greifswald phone: ++49 3834 864073 ++49 3834 864072 (1)
Institute of Life Course and Medical Sciences, University of Liverpool, United Kingdom (1)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n 18016, Granada-Spain (1)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n 18016 Armilla (Granada). Spain (1)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC. Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n.18016 Armilla (Granada). Spain (1)
Instituto de Parasitología y Biomedicina "López - Neyra", CSIC. Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n. 18016, Granada-Spain (1)
Karolinska Institutet, Stockholm, Sweden (1)
Laboratory Medicine, UZ Leuven Hospitals, Belgium Principal investigator of the lab of Clinical and Diagnostic Immunology at KU Leuven (1)
Laboratory of Immunity & Cell Communication, BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic (1)
Mass Spectrometry Facility Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ (1)
Medical Inflammation Research, Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden (1)
Neuroimmunology and MS Research University Hospital Zurich Frauenklinikstrasse 26 8091 Zurich Switzerland (1)

Keyword

Diabete Mellitus (1)
Sickle Cell Disease (1)
Sjogren’s Syndrome (1)
Neglected Diseases (1)
Orphan Diseases (1)
Rare Disease Research (1)
Registries (1)
Batten Disease (1)
Mucolipidosis IV (1)
Undiagnosed (1)
Uncommon Disease (1)
Hypersomnia (1)
Marinesco-Sjogren Syndrome (1)
4p-/Wolf-Hirschhorn Syndrome (1)
Wiedermann-Steiner Syndrome (1)
Hemophagocytic Lymphohistiocytosis (HLH) (1)
Behcet’s Disease (1)
Jansen metaphyseal chondrodysplasia (1)
Chronic recurrent multifocal osteomyelitis (CRMO) (1)
Hereditary Sensory and Autonomic Neuropathy (1)
Nephropathic infantile cystinosis (1)
Ocular cystinosis (1)
Spinal Bulbar Muscular Atrophy (SBMA) (1)
Mucolipidosis (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Shine Syndrome (1)
Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

IsPrivate

False (5)

Submitter Keywords

FROG (4)

Study type

Transcription profiling by array (157)
RNA-seq of coding RNA (20)
Transcription profiling by RT-PCR (9)
Proteomic profiling by array (9)
RNA-seq of coding RNA from single cells (8)
Methylation profiling by array (7)
Unknown experiment type (6)
Other (3)
RNA-seq of non coding RNA (3)
ChIP-seq (2)
MicroRNA profiling by array (2)
Observational (2)
Human - Two-color microarray (1)
Animal - One-color microarray (1)
Human - Methylation microarray (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Genotyping by array (1)
Antigen profiling (1)
MicroRNA profiling by high throughput sequencing (1)
Bisulfite-seq (1)
ATAC-seq (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)
Observational patient registry (1)
Interventional (1)

Release Date

2022 (480)
2023 (458)
2025 (428)
2021 (403)
2024 (343)
2020 (314)
2019 (258)
2018 (228)
2017 (200)
2016 (187)
2015 (181)
2014 (150)
2012 (132)
2013 (128)
2011 (89)
2010 (82)
2009 (68)
2026 (60)
2008 (48)
2007 (27)
2006 (21)
2005 (15)
2004 (9)
2001 (7)
2003 (5)
2000 (2)
1998 (2)
2002 (1)
1999 (1)

Location

United States (3)
Germany (1)
Canada (1)
Australia (1)
Austria (1)
France (1)

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Succinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

Succinate is implicated in rheumatoid arthritis (RA) and other inflammatory diseases via its receptor, G protein-coupled receptor 91 (GPR91). Despite its therapeutic potential, conflicting reports on its inflammatory roles have hindered GPR91-targeted treatm...

2026-02-05 | MTBLS13828 | MetaboLights

HumanMethylation450 (450k) data for 79 rheumatoid arthritis disease discordant monozygotic twin pairs

This project contains genome-wide DNA methylation data generated using the HumanMethylation450 BeadChip (Illumina), for 79 rheumatoid arthritis (RA) discordant monozygotic twin pairs. By investigating disease discordant monozygotic twins, DNA methylation can be assessed without the confounding influ...

ORGANISM(S): Homo sapiens

2018-07-24 | E-MTAB-6988 | biostudies-arrayexpress

Gene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance

During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of ...

ORGANISM(S): Rattus norvegicus

2011-11-16 | E-GEOD-31314 | biostudies-arrayexpress

Collagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma

Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...

2015-11-04 | MTBLS243 | MetaboLights

Plasma metabolomic and lipidomic signatures characteristic of treatment non-response in rheumatoid arthritis

Objectives: This study aimed to investigate plasma metabolomic and lipidomic profiles in rheumatoid arthritis (RA) to identify potential biomarkers for distinguishing treatment responses.

Methods: Plasma samples...

2026-06-02 | MTBLS13243 | MetaboLights

Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy

Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...

2025-08-14 | MTBLS6213 | MetaboLights

Plasma metabolomic and lipidomic signatures characteristic of treatment non-response in rheumatoid arthritis

Objectives: This study aimed to investigate plasma metabolomic and lipidomic profiles in rheumatoid arthritis (RA) to identify potential biomarkers for distinguishing treatment responses.

Methods: Plasma samples w...

2026-06-02 | MTBLS13238 | MetaboLights

Comparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an...

2026-02-02 | MTBLS13820 | MetaboLights

Transcription profiling of DBA/1J mouse with collagen induced arthritis

Time course of collagen-induced arthritis in DBA/1J male mice, synchronized on day 28 with 10ug LPS

ORGANISM(S): Mus musculus

2009-11-16 | E-TABM-661 | biostudies-arrayexpress

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental factors. Both variants of autoimmune susceptibility genes and environment are involved in the generation of aberrant epigenetic profiles in a cell-sp...

ORGANISM(S): Homo sapiens

2013-05-07 | E-GEOD-46650 | biostudies-arrayexpress

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