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ProteomicsTwo independent proteomic approaches provide the most comprehensive analysis of the synovial fluid proteome in responders and non-responders to Autologous Chondrocyte Implantation
Background: Results obtained from our previous study using a label-free quantitation (LF) proteomic approach in which dynamic range compression was used to profile lower abundance proteins, demonstrated few proteins that were differentially abundant within the synovial fluid (SF) when comparing Auto...
ORGANISM(S): Homo sapiens (Human) 
2018-05-03 | PXD008321 | Pride
Autologous chondrocyte implantation (aci)  itraq proteomics  label-free quantification proteomics  synovial fluid  cartilage repair  osteoarthritis 
ProteomicsProteomic profiles of synovial fluids derived from autologous chondrocyte implantation surgery
The pathology of failure in currently used biological treatments (cell therapies and microfracture) for cartilage repair or early osteoarthritis (OA) is poorly understood. We aimed to identify a reliable panel of biological predictors, present in synovial fluid, which can be used in the preoperative...
ORGANISM(S): Homo sapiens (Human) 
2017-07-04 | PXD005220 | Pride
Label-free  synovial fluid  proteominer  osteoarthritis  cell therapy 
UnknownRegenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy.
Not available
S-EPMC6466051 | biostudies-literature
UnknownMatrix-Induced Autologous Chondrocyte Implantation With Autologous Bone Grafting for Osteochondral Lesions of the Femoral Trochlea.
Not available
S-EPMC6470391 | biostudies-literature
UnknownAll-Arthroscopic Membrane Autologous Chondrocyte Implantation for Femoral Cartilage Defects.
Not available
S-EPMC12712496 | biostudies-literature
UnknownFour cases report: Treatment of knee joint cartilage defects using autologous chondrocyte patch implantation.
Not available
S-EPMC9679023 | biostudies-literature
TranscriptomicsReprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes (RNA-Seq)
Chondrocyte-based cartilage repair strategies such as autologous chondrocyte implantation (ACI) require extensive in vitro expansion to obtain clinically relevant cell numbers. However, monolayer expansion drives chondrocyte dedifferentiation, reducing matrix-forming capacity and contributing to var...
ORGANISM(S): Homo sapiens 
2026-04-14 | GSE327285 | GEO
UnknownCostal Chondrocyte-Derived Pellet-Type Autologous Chondrocyte Implantation versus Microfracture for Repair of Articular Cartilage Defects: A Prospective Randomized Trial.
Not available
S-EPMC8808917 | biostudies-literature
UnknownClinical outcome is significantly better with spheroid-based autologous chondrocyte implantation manufactured with more stringent cell culture criteria.
Not available
S-EPMC9718150 | biostudies-literature
UnknownFocal cartilage defects in the knee - a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement.
Not available
S-EPMC4784272 | biostudies-literature
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