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GenomicsEffect of autophagy deficiency in endothelial cells
Effect of autophagy deficiency in endothelial cells
PRJNA987622 | ENA
TranscriptomicsT-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy
Background: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development. However, intrinsic molecular and cellular consequences of either TIA1 or...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-43077 | biostudies-arrayexpress
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD019946 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-05 | PXD019947 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
GenomicsBCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy
BCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy
PRJNA1308978 | ENA
TranscriptomicsTranscriptional profile in the colon in response to C. rodentium infection.
The identification of Atg16L1 as a susceptibility gene has implicated antibacterial autophagy in the pathogenesis of Crohn's disease, a major type of inflammatory bowel disease (IBD). However, the role of Atg16L1 during extracellular bacterial infections of the intestine has not been sufficiently ex...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-49109 | biostudies-arrayexpress
TranscriptomicsMitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Mitochondrial fusion and fission proteins regulate mitochondrial quality control and mitochondrial metabolism. In turn, mitochondrial dysfunction is associated with aging, although its causes are still under debate. Here, we show that aging is characterized by a progressive reduction of Mitofusin 2 ...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71501 | biostudies-arrayexpress
TranscriptomicsEffect of autophagy deficiency in endothelial cells
Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vi...
ORGANISM(S): Homo sapiens 
2023-07-01 | GSE235785 | GEO
TranscriptomicsBCL11A deficiency protects epidermis from UVB-induced damage through promotion of autophagy
As a major environmental pathogenic factor for various skin diseases, UVB radiation leads to oxidative stress and biomacromolecule damage. Autophagy is a highly conserved catabolic process and serves as one of the main mechanisms to maintain cellular homeostasis. Here, by CRISPR/Cas9-mediated gene d...
ORGANISM(S): Homo sapiens 
2025-08-27 | GSE306030 | GEO
UnknownAutophagy deficiency activates rDNA transcription.
Not available
S-EPMC9225380 | biostudies-literature
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