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TranscriptomicsGene expression profiling of the response to interferon beta in EBV-transformed and primary B cells of patients with multiple sclerosis
To identify gene expression changes and pathways induced by interferon-? (IFN-?) in B cells, we studied the in vitro response of EBV-transformed B cells (lymphoblast cell lines-LCLs). LCLs were derived from an MS patient repository. Whole genome expression analysis identified 115 genes that were mor...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-58240 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of monocytes and T cells' response to interferon beta
The research hypothesis was that the unique expression profile of monocytes in response to Interferon-beta (IFN-β) might be masked by the response profile of the more abundant T cells. The analysis of monocytes response may highlight novel IFN-β functions and pathways that have not been recognized...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-34627 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of methylome and transcriptome in human blood identifies extensive sex and immune cell-specific differentially methylated regions [methylation]
DNA methylation has an impact on regulation of gene expression, however the relation between the two is complex. By performing an integrative analysis of the methylome and transcriptome of the four main circulating immune cell-subsets from healthy females, namely B cells, monocytes, CD4 and CD8 T ce...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-71244 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of methylome and transcriptome in human blood identifies extensive sex and immune cell-specific differentially methylated regions [expression]
DNA methylation has an impact on regulation of gene expression, however the relation between the two is complex. By performing an integrative analysis of the methylome and transcriptome of the four main circulating immune cell-subsets from healthy females, namely B cells, monocytes, CD4 and CD8 T ce...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-71115 | biostudies-arrayexpress
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