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TranscriptomicsMolecular Profiling of the Developing Axial Skeleton: A role for Tgfbr2 in the Development of the Intervertebral Disc.
This SuperSeries is composed of the following subset Series: GSE18647: Gene expression in embryonic intervertebral disc and vertebrae. GSE18648: TGF-beta and BMP mediated gene expression in cultured sclerotome. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18649 | biostudies-arrayexpress
TranscriptomicsTGF-beta and BMP mediated gene expression in cultured sclerotome.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-beta superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue re...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18648 | biostudies-arrayexpress
TranscriptomicsGene expression in embryonic intervertebral disc and vertebrae.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-ß superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue resul...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18647 | biostudies-arrayexpress
GenomicsAxial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis and retinoic acid
Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis and retinoic acid
PRJNA610053 | ENA
TranscriptomicsAxial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis and retinoic acid
Vertebrate axial skeletal patterning is controlled by coordinated collinear expression of Hox genes and axial level-dependent activity of Hox protein combinations. Transcription factors of the Meis family act as cofactors of Hox proteins and profusely bind to Hox complex DNA, however their roles in ...
ORGANISM(S): Mus musculus 
2020-12-22 | GSE146301 | GEO
GenomicsPre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development
Pre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development
PRJNA958096 | ENA
TranscriptomicsAffymetrix SNP 6.0 array data for chordoma samples
Chordomas are rare, low to intermediate grade malignant bone tumors of the axial skeleton, believed to originate from the notochord. Treatment options are limited and mainly restricted to surgical excision, as chordomas have been proven to be largely resistant to conventional ionizing radiation and ...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-25720 | biostudies-arrayexpress
GenomicsPre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [ATAC-seq]
Pre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [ATAC-seq]
PRJNA958101 | ENA
GenomicsPre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [ChIP-seq]
Pre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [ChIP-seq]
PRJNA958105 | ENA
GenomicsPre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [scRNA-seq]
Pre-Hypertrophic Chondrogenic Enhancer Landscape of Limb and Axial Skeleton Development [scRNA-seq]
PRJNA958100 | ENA
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