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TranscriptomicsEffect of AZD1208 on gene expression in recurrent resistant Myc-CaP tumors grown in castrated mice.
AZD1208 is a novel PIM kinase inhibitor that we have shown inhibits tumorigenesis in tissue recombination models, Myc-CaP allograft models, and human prostate cancer xenografts. We sought to determine the intracellular pathways that are responsible for the anti-tumor effect. To this end we used the ...
ORGANISM(S): Mus musculus 
2014-12-24 | E-GEOD-59106 | biostudies-arrayexpress
GenomicsPIM Kinase Inhibitor AZD1208 Treats MYC-driven Prostate Cancer
PIM Kinase Inhibitor AZD1208 Treats MYC-driven Prostate Cancer
PRJEB5525 | ENA
UnknownPIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells.
Not available
S-EPMC6497463 | biostudies-literature
UnknownPhase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.
Not available
S-EPMC5988656 | biostudies-literature
UnknownPan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells.
Not available
S-EPMC6473293 | biostudies-literature
UnknownProtein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia.
Not available
S-EPMC5650058 | biostudies-literature
TranscriptomicsEffect of AZD1208 on gene expression in recurrent resistant Myc-CaP tumors grown in castrated mice.
AZD1208 is a novel PIM kinase inhibitor that we have shown inhibits tumorigenesis in tissue recombination models, Myc-CaP allograft models, and human prostate cancer xenografts. We sought to determine the intracellular pathways that are responsible for the anti-tumor effect. To this end we used the ...
ORGANISM(S): Mus musculus 
2014-12-24 | GSE59106 | GEO
UnknownAZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.
Not available
S-EPMC3916880 | biostudies-literature
UnknownThe novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.
Not available
S-EPMC4741975 | biostudies-literature
UnknownInsights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study.
Not available
S-EPMC6862308 | biostudies-literature
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