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GenomicsComprehensive analysis of circular RNA profiling in AZD9291-resistant non-small cell lung cancer cell lines
Comprehensive analysis of circular RNA profiling in AZD9291-resistant non-small cell lung cancer cell lines
PRJNA1095434 | ENA
TranscriptomicsAcquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling
To compare gene copy number in cell populations with acquired resistance to specified EGFR inhibitors to parental cell lines. The aim of the experiment was to determine whether gain or loss of copy number of particular genes was associated with resistance to particular EGFR inhibitors. Comparing gen...
ORGANISM(S): Homo sapiens 
2015-04-14 | E-GEOD-59239 | biostudies-arrayexpress
UnknownThe third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma.
Not available
S-EPMC6533774 | biostudies-literature
UnknownAcquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model.
Not available
S-EPMC5895014 | biostudies-literature
UnknownNanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo.
Not available
S-EPMC6219431 | biostudies-literature
UnknownRefinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity.
Not available
S-EPMC8577418 | biostudies-literature
UnknownAZD9291 Resistance Reversal Activity of a pH-Sensitive Nanocarrier Dual-Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC.
Not available
S-EPMC7816715 | biostudies-literature
UnknownAcquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.
Not available
S-EPMC4771182 | biostudies-literature
UnknownDYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291.
Not available
S-EPMC6815810 | biostudies-literature
UnknownOvercoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.
Not available
S-EPMC5668147 | biostudies-literature
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