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MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
TranscriptomicsEstrogen-Related Receptor-a Coordinates Transcriptional Programs Essential for Exercise Tolerance and Muscle Fitness
The molecular mechanisms involved in the coordinate regulation of the metabolic and structural determinants of muscle endurance are still poorly characterized. To help elucidate the role of ERRa in this process, gene expression arrays were employed resulting in the identification of ERRa-dependent g...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-61712 | biostudies-arrayexpress
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