B-acute lymphocytic leukemia

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Transcriptomics (950)
Genomics (246)
Unknown (195)
Clinical (34)
Proteomics (19)
Other (5)
Metabolomics (5)
Genomic (4)
Models (1)

Organisms

Homo sapiens (868)
Mus musculus (248)
Methanococcus maripaludis S2 (9)
Rattus norvegicus (7)
Danio rerio (5)
Bos indicus (4)
Canis lupus familiaris (3)
Arabidopsis thaliana (3)
Macaca mulatta (3)
Gossypium hirsutum (2)
Glycine max (2)
Caenorhabditis elegans (2)
Gallus gallus (2)
Populus cathayana (1)
Populus yunnanensis (1)
Phalaenopsis aphrodite subsp. formosana (1)
Ipomoea batatas (1)
Chlamydia trachomatis (1)
Cannabis sativa (1)
Fusobacterium nucleatum (1)
Pan troglodytes (1)
Oryza sativa Indica Group (1)
Macaca fascicularis (1)
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Schizosaccharomyces pombe (1)
Nicotiana tabacum (1)
Cricetulus griseus (1)
Hordeum vulgare (1)
Triticum aestivum (1)

Organisms

Homo sapiens (19)
Mus musculus (6)

Repository

biostudies-arrayexpress (1045)
EGA (110)
ENA (27)
geo (20)
MassIVE (13)
MetaboLights (5)
dbGaP (4)
iProX (2)
jPOST (2)
pride (2)
ExpressionAtlas (1)
Cell Collective (1)
GPMDB (1)

Tissue

Spinal ganglion (1)
Bone marrow (1)
Blood plasma (1)
B cell (1)

Disease

Colon carcinoma (2)
Oral squamous cell carcinoma (1)
Endometrium adenocarcinoma (1)
Gastric tubular adenocarcinoma (1)
Undifferentiated carcinoma (1)
Amelanotic melanoma (1)
Salivary gland squamous cell carcinoma (1)
Endometrial endometrioid adenocarcinoma, variant with squamous differentiation (1)
Ovarian endometrioid adenocarcinoma (1)
Gliosarcoma (1)
B-cell prolymphocytic leukemia (1)
Childhood acute monocytic leukemia (1)
Mucinous gastric adenocarcinoma (1)
Hereditary thyroid gland medullary carcinoma (1)
Extrarenal rhabdoid tumor (1)
Meningioma (1)
Leiomyoma, epithelioid (1)
Primary effusion lymphoma (1)
Cecum adenocarcinoma (1)
Bronchioloalveolar carcinoma (1)
Adenosquamous lung carcinoma (1)
Pancreatic adenosquamous carcinoma (1)
Laryngeal squamous cell carcinoma (1)
Duodenal adenocarcinoma (1)
Adult B acute lymphoblastic leukemia (1)
Uterine leiomyosarcoma (1)
Endometrial stromal sarcoma (1)
Chronic eosinophilic leukemia (1)
Ampulla of Vater adenocarcinoma (1)
Cutaneous melanoma (1)

Technology Type

Illumina HiSeq 2000 (5)
ILLUMINA, Illumina HiSeq 2000 (4)
Mass spectrometry (3)
Illumina HiSeq 2500 (2)
Mass spectrometry assay (2)
Mass Spectrometry (2)
Illumina MiSeq, Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 2000 (ILLUMINA) (1)
Illumina HiSeq 2500, ILLUMINA (1)
NextSeq 500, Illumina HiScanSQ (1)
454 GS FLX Titanium (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
Illumina MiSeq (1)
Bottom-up proteomics (1)
Shotgun proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (40)
NextSeq 500 (32)
Illumina HiSeq 2500 (21)
Illumina HiSeq 2000 (14)
NextSeq 550 (9)
Illumina HiSeq 4000 (6)
NextSeq 2000 (4)
Illumina Genome Analyzer II (3)
Illumina NovaSeq X (3)
Illumina MiSeq (3)
Illumina HiSeq 3000 (3)
454 GS FLX+ (2)
Axon- GenePix4000B (2)
G2565BA DNA microarray scanner [Agilent] (2)
Illumina HiSeq 1500 (2)
Affymetrix GCS 3000 (1)
GeneChip® Pico Kit (Affymetrix) (1)
Affymetrix Clariom™ S (400 Format) (1)
NextSeq 500, 75 bp single end lane (1)
MacBook Pro 64Gb RAM; 16-core (1)
Qubit 2.0 Fluorometer; Agilent TapeStation 4200 (1)
FACS (1)
Agilent SureScan High Resolution scanner (1)
DNA Microarray Scanner (Model G2505C, Agilent Technologies) (1)
GenePix 4000B [Axon] (1)
HiSeq X Five (1)
Not applicable (1)
Affymetrix Fluidics Station (1)
GeneChip Scanner 3000 7G (1)
ArrayWoRx Biochip Reader [Applied Precision] (1)

Publication Date

2015 (127)
2013 (119)
2014 (118)
2011 (99)
2012 (90)
2016 (82)
2010 (72)
2008 (60)
2009 (47)
2021 (32)
2017 (30)
2022 (27)
2019 (27)
2025 (25)
2024 (24)
2026 (23)
2023 (20)
2007 (17)
2018 (16)
2020 (14)
2005 (10)
2006 (8)
2004 (2)

CHEBI ID

CHEBI:71616 (2)
CHEBI:143269 (2)
CHEBI:134543 (2)
CHEBI:81015 (2)
CHEBI:29023 (2)
CHEBI:165860 (2)
CHEBI:68567 (2)
CHEBI:1556 (2)
CHEBI:133583 (2)
CHEBI:166739 (2)
CHEBI:133176 (2)
CHEBI:89379 (2)
CHEBI:47772 (2)
CHEBI:176478 (2)
CHEBI:133532 (2)
CHEBI:133559 (2)
CHEBI:133186 (2)
CHEBI:16175 (2)
CHEBI:53014 (2)
CHEBI:68505 (2)
CHEBI:71018 (2)
CHEBI:36315 (2)
CHEBI:133693 (2)
CHEBI:133677 (2)
CHEBI:84324 (2)
CHEBI:19660 (2)
CHEBI:23098 (2)
CHEBI:90344 (2)
CHEBI:77761 (2)
CHEBI:43419 (2)

Metabolite Name

N-methylhydroxyproline** (2)
3-methylglutarate/2-methylglutarate (2)
N-acetyl-cadaverine (2)
N1,N12-diacetylspermine (2)
N-methylalanine (2)
N-acetyl-isoputreanine* (2)
3beta,7alpha-dihydroxy-5-cholestenoate (2)
3-hydroxystachydrine* (2)
L-urobilin (2)
Isoursodeoxycholate (2)
Taurocholenate sulfate* (2)
Hyocholate (2)
Vanillic alcohol sulfate (2)
Tryptophan betaine (2)
Taurolithocholate 3-sulfate (2)
Pregnenolone sulfate (2)
Glycohyocholate (2)
Glycodeoxycholate (2)
Glycochenodeoxycholate (2)
Gamma-CEHC (2)
Delta-tocopherol (2)
Arachidonoyl ethanolamide (2)
Alpha-hydroxycaproate (2)
3beta-hydroxy-5-cholestenoate (2)
Methyl-4-hydroxybenzoate sulfate (2)
3-hydroxypyridine sulfate (2)
2-aminophenol sulfate (2)
N-acetyl-1-methylhistidine* (2)
N-palmitoylglycine (2)
4-cholesten-3-one (2)

First Public Date

2024 (7)
2026 (5)
2022 (4)
2018 (4)
2016 (2)
2015 (2)
2021 (1)
2020 (1)
2014 (1)

Study status

Completed (21)
Terminated (6)
Recruiting (4)
Withdrawn (2)
Not yet recruiting (1)

Study type

Transcription profiling by array (576)
RNA-seq of coding RNA (139)
ChIP-seq (86)
Methylation profiling by array (37)
Comparative genomic hybridization by array (26)
Genotyping by array (16)
RNA-seq of coding RNA from single cells (15)
Other (14)
Cell line - High-throughput sequencing (13)
RNA-seq of non coding RNA (11)
Methylation profiling by high throughput sequencing (10)
Transcription profiling by tiling array (9)
MicroRNA profiling by array (8)
RNA-seq of total RNA (8)
Unknown experiment type (7)
ChIP-chip by tiling array (7)
DNA-seq (7)
ATAC-seq (6)
ChIP-chip by array (5)
RIP-seq (5)
Transcription profiling by RT-PCR (4)
Human - High-throughput sequencing (3)
Cell line - One-color microarray (3)
RNAi profiling by array (3)
Transcription profiling by SAGE (2)
Differential (2)
Human - Two-color microarray (2)
Animal - One-color microarray (2)
Human - One-color microarray (2)
MicroRNA profiling by high throughput sequencing (2)

Release Date

2015 (137)
2014 (125)
2013 (123)
2011 (105)
2012 (95)
2016 (92)
2010 (76)
2008 (60)
2022 (50)
2023 (47)
2021 (47)
2009 (47)
2017 (37)
2019 (33)
2024 (30)
2020 (28)
2018 (27)
2025 (24)
2026 (18)
2007 (17)
2005 (11)
2006 (8)
2004 (2)
2003 (1)

Lab affiliation

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Denmark (1)
Universidade Estadual do Oeste do Paraná, Reitoria, Campus Universitário de Francisco Beltrão. Rua Maringa 1200 - Centro de Ciências da Saúde centro 86010000 - Francisco Beltrão, PR - Brasil fone. +55 46 35204886 (1)

Location

United States (30)
Italy (5)
Germany (3)
Canada (2)
India (1)
South Korea (1)
France (1)
Australia (1)

Keyword

Fludarabine (9)
Fludarabine phosphate (9)
Mycophenolic Acid (8)
Cyclosporine (8)
Cyclosporins (8)
Cyclophosphamide (5)
Tacrolimus (4)
Rituximab (4)
Bendamustine Hydrochloride (2)
Vorinostat (2)
Busulfan (2)
Methotrexate (2)
Lenalidomide (2)
Etoposide (2)
Etoposide phosphate (2)
Antineoplastic Agents, Immunological (2)
Antibodies (2)
Immunoglobulins (2)
Antibodies, Monoclonal (2)
Deferasirox (1)
Veliparib (1)
Allogeneic hematopoietic stem cell transplantation (1)
Hematologic malignancies (1)
Intestinal microbiota (1)
Dexrazoxane (1)
Razoxane (1)
Obatoclax (1)
Fecal Microbiota Transplantation (1)
Intestinal dysbiosis (1)
Transplantation (1)

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GREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression

Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationshi...

2024-09-23 | MTBLS10103 | MetaboLights

Pax5 restoration in a mouse model of B progenitor acute lymphoblastic leukemia

Hypomorphic mutations of PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs), however their functional consequences remain undefined. Here we employ advanced transgenic RNAi in mice to suppress endogenous Pax5 expression in the hematopoietic compartment in vivo, which co-o...

ORGANISM(S): Mus musculus

2014-06-18 | E-GEOD-52870 | biostudies-arrayexpress

Rearrangement of CRLF2 in B-progenitor and Down syndrome associated acute lymphoblastic leukemia

Chromosomal aneuploidy and translocations are hallmarks of acute lymphoblastic leukemia (ALL), but many patients lack a recurring chromosomal alteration. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that results in the ex...

ORGANISM(S): Homo sapiens

2009-10-18 | E-GEOD-16724 | biostudies-arrayexpress

Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights

Identification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia

Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...

2025-02-03 | MTBLS11858 | MetaboLights

Comparative analysis of systemic and tumor microenvironment proteomes of children with b-cell acute lymphocytic leukemia at diagnosis and after induction treatment.

Among the childhood diseases, B-cell acute lymphocytic leukemia (B-ALL) is the most frequent type of cancer. In spite of recent advances concerning disease treatment, cytotoxic chemotherapy remains as the first line of treatment in several countries, and the modifications induced by such drugs in th...

ORGANISM(S): Homo sapiens (Human)

2020-12-14 | PXD021584 | Pride

Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages

BCR–ABL1+ precursor B-cell acute lymphoblastic leukemia (BCR– ABL1+ B-ALL) is an aggressive hematopoietic neoplasm characterized by a block in differentiation due in part to the somatic loss of transcription factors required for B-cell development. We hypothesized that overcoming this differentiatio...

ORGANISM(S): Homo sapiens

2015-04-01 | E-GEOD-66792 | biostudies-arrayexpress

Identification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia

2025-02-03 | MTBLS11844 | MetaboLights

Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia [ChIP-seq]

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. We performed DNA methylation (HELP array) and gene expression profiling in 215 samples of adult B-lineage acute lymphoblastic leukemia (ALL) and 12 normal preB samples. Adult B-lin...

ORGANISM(S): Homo sapiens

2012-11-27 | E-GEOD-38403 | biostudies-arrayexpress

RNA-seq of primary human bone marrow derived mesenchymal stromal cells from pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients

To investigate the identity of the tumor microenvironment in acute lymphoblastic leukemia (B-ALL), the transcriptome of mesenchymal stromal cells derived from bone marrow of three pediatric patients at the onset of the disease was analyzed and compared with its normal counterpart.

ORGANISM(S): Homo sapiens

2021-10-16 | E-MTAB-10838 | biostudies-arrayexpress

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1462 Results

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