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MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
MetabolomicsMetabolomics of human primary B-ALL cells treated by BCR-Abl1 inhibitor, STI571, and p190 BCR-Abl+ BAF3 cells with ASS1 knockdown
Analyze the Metabolomics changes in B-ALL cells after the treatment of imatinib and p190+ BAF3 cells with ASS1 knockdown or left untreated. two methods as the below LC-MS description showed were used.
2026-07-08 | MTBLS14638 | MetaboLights
MetabolomicsQuantitative lipidomics of TFG-deficient B cells
Not available
ORGANISM(S): Mus musculus 
ST002360 | MetabolomicsWorkbench
MetabolomicsMetabolomics study comparing SCAP KO and WT B cells
Not available
ORGANISM(S): Mus musculus 
ST002322 | MetabolomicsWorkbench
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profile of activated primary B cells and miR181b overexpressing primary B cells
This SuperSeries is composed of the following subset Series: GSE12156: Murine spleen B cells miR181b vs control (G4122A) GSE12158: Murine spleen B cells miR181b vs control (G4122F) GSE12176: microRNA expression profile of activated versus non activated primary B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2008-08-20 | E-GEOD-12186 | biostudies-arrayexpress
TranscriptomicsIdentification of IL-21-induced STAT3 dependent genes in human B cells
IL-21 induces B cell activation, and differentiation into antibody-secreting plasmablasts in vitro. This process is abolished by loss-of function mutations in STAT3 We used microarrays to identify genes that are induced by IL-21 in a STAT3-dependent manner Sort-purified naïve B cells from four heal...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-51587 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human memory B cells to plasma cells differentiation time course
In vitro model of differentiation of memory B cells into plasmablasts and plasma cells.
ORGANISM(S): Homo sapiens 
2009-10-01 | E-MEXP-2360 | biostudies-arrayexpress
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [H3K4me2 and H3K4me3]
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35914 | biostudies-arrayexpress
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