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GenomicsGene expression profile of PMM2_CDG (Congenital Disorder of Glycosylation) B lymphoblastoid cell lines (B-LCL)
Gene expression profile of PMM2_CDG (Congenital Disorder of Glycosylation) B lymphoblastoid cell lines (B-LCL)
PRJNA605976 | ENA
TranscriptomicsGene expression profile of PMM2_CDG (Congenital Disorder of Glycosylation) B lymphoblastoid cell lines (B-LCL)
Glycosylation of proteins is an important post-translational modification that comprises two major stages: synthesis and attachment of glycans in the endoplasmic reticulum (ER), and glycan remodeling in the ER and Golgi apparatus (GA). Genetic disorders impairing a step of this process give rise to ...
ORGANISM(S): Homo sapiens 
2022-01-22 | GSE145082 | GEO
GenomicsImpact of homozygous loss-of-function mutations in the LARP7 gene on the pA+ transcriptome of a B-lymphoblastoid cell line (B-LCL)
Impact of homozygous loss-of-function mutations in the LARP7 gene on the pA+ transcriptome of a B-lymphoblastoid cell line (B-LCL)
PRJNA556476 | ENA
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
TranscriptomicsEBV Modulates Host Cell microRNA-194 to Promote IL-10 Production and B Lymphoma Cell Survival
The purpose of this study was to investigate the effect of EBV infection on host cell miR and to characterize the miRNome in EBV+ B cell lymphomas from patients with PTLD. A qPCR array was used to measure the expression level of 377 previously identified miRs from RNA isolated from three sources: to...
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-61283 | biostudies-arrayexpress
TranscriptomicsIdentification of MEF2B, EBF1, and IL6R as chromosome bound targets of EBNA1 essential for EBV infected B-lymphocyte survival
EBNA1 is the EBV-encoded nuclear antigen required for viral episome maintenance during latency. EBNA1 is a sequence specific DNA binding protein with high affinity binding sites for the viral genome, especially OriP. EBNA1 can also bind sequence specifically to a large number of sites in the host ...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-73887 | biostudies-arrayexpress
GenomicsCombinatorial Control of RBP-jk and EBF1 Chromosome Occupancy induced by viral co-activator EBNA2 [ChIP-seq]
Gene expression programs depend on sequence-specific DNA binding transcription factors, but the mechanisms that control the selective binding of these factors in a chromosomal and genomic context remain enigmatic. Here, we show that two master regulators of B-cell fate, namely EBF1 and RBP-jk, sho...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-75503 | biostudies-arrayexpress
ProteomicsExtending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling
Defining the repertoire of peptides presented by the major histocompatibility complex class I (MHC I) is a key step towards the identification of relevant antigens for cancer immunotherapy. However, the identification of the cancer-specific antigens is a significant analytical challenge in view of t...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD017918 | Pride
Tmt Minor antigens Mhc Tumor specific antigens Faims 
TranscriptomicsTranscription profiling and proteomic profiling of human B-LCL cell lines (TAP1/2 +/+ and TAP1/2 -/-) to analyse HLA peptide repertoire
The TAP transporter is responsible for transferring cytosolic peptides into the ER where they can be loaded onto MHC molecules. Deletion of TAP results in a drastic reduction of MHC surface expression and alters the presented peptide pattern. Using the TAP deficient cell line LCL721.174 and its TAP ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9437 | biostudies-arrayexpress
Transcriptomics3D genome landscape of Epstein-Barr Virus oncoproteins and virus activated NF-kB in lymphoblastoid cells
Epstein-Barr Virus (EBV) encoded Nuclear Antigens (EBNAs) and virus activated NF-B subunits mostly bind to enhancers in EBV transformed lymphoblastoid cells lines (LCLs). Using LCL 3D genome organization map that links EBV enhancers to promoters, we built the most comprehensive virus regulome. EBV ...
ORGANISM(S): Homo sapiens 
2019-07-01 | GSE101666 | GEO
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