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MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle
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ORGANISM(S): Mus musculus 
ST002140 | MetabolomicsWorkbench
TranscriptomicsInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
B cells from anonymous adenoid donors were isolated and sorted for naïve B cells, which were subsequently infected with a reference EBV strain (2089_B95-8) using a defined multiplicity of infection. Infection of resting B cells with EBV induces their activation, their proliferation, and subsequent i...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7805 | biostudies-arrayexpress
TranscriptomicsEpigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
The increase in atopic diseases has occurred in such a short period of time that it becomes difficult to be attributed only to genetic factors, which usually need more prolonged time periods to manifest. In this setting during the last decade, the science of epigenetics has increasingly developed of...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-26080 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma
In this study we present the first genome-wide expression profiling of peripheral B cells by massive parallel RNA sequencing in patients with allergic asthma validating the discovery potential of this approach in allergy. RNA-seq was used to asses expression differences in B CD19 Lymphocytes from ho...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-52742 | biostudies-arrayexpress
TranscriptomicsInteractions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Full title: Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication In order to identify extra cellular signals that promote B lymphocyte development we created a database with approximately 400 receptor ligand...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-19729 | biostudies-arrayexpress
TranscriptomicsZfx controls BCR-induced proliferation and survival of B lymphocytes
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeos...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-13547 | biostudies-arrayexpress
TranscriptomicsmiRNA profiles of tonsilar B and T lymphocytes
miRNA profiling of human tonsilar B lymphocytes (naïve B cells, centroblasts and memory B cells) and tonsilar T cells, analyzing the 470 human miRNAs present in miRBase V9.1. B cell subpopulations and T cells were purified using specific antibodies, magnetic beads and the AutoMACS system (Miltenyi B...
ORGANISM(S): Homo sapiens 
2009-01-27 | E-GEOD-12934 | biostudies-arrayexpress
TranscriptomicsB16 versus B16B1
Analysis of gene expression patterns in cancer improved the understanding the mechanisms underlying the process of metastatic progression. Recent studies have attributed an important role to B-1 cells, a subset of B lymphocytes, in melanoma progression. It was already demonstrated that in vitro inte...
ORGANISM(S): Mus musculus 
2013-06-05 | E-MEXP-3599 | biostudies-arrayexpress
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