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UnknownFinal 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naive Chronic Myeloid Leukemia Patients Trial.
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S-EPMC5118045 | biostudies-literature
TranscriptomicsExpression data from untreated and ATP treated AML blasts
In the present study, we investigated whether, and to what extent, P2Rs and their ligands are involved in the regulation of AML cells. Our findings show that AML blasts express several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimul...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-30903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human essential Thrombocythemia (ET) vs normal (baseline) megakaryocytes
Essential Thrombocythemia (ET) patients, as well as normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-567 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human eessential thrombocythemia megakaryocytes versus normal megakaryocytes
Normal donors BM CD34+ cells were differentiated in thrombopoietin-treated liquid suspension cultures. Briefly, CD34+ cells (80,000 /mL) were resuspended in a serum-free medium in the presence of 100 ng/mL of human recombinant thrombopoietin (TPO; Genzyme, Boston, MA). Every 3 days, viable cells wer...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-997 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells and treatment with UTP and CXCL12
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and non-peptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key-factors of inflammation and related chemotactic respons...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5168 | biostudies-arrayexpress
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