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GenomicsDevelopmental dynamics of DNA accessibility during flower development [DNaseI-Seq]
Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programmes. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which...
ORGANISM(S): Arabidopsis thaliana 
2014-02-03 | E-GEOD-46894 | biostudies-arrayexpress
TranscriptomicsmRNA expression upon reconstitution of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP
Micro RNAs (miRNAs) miR-130a, miR-203 and miR-205 are jointly downregulated in prostate cancer and act as repressors of AR-signaling. MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. Reconstitu...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-17315 | biostudies-arrayexpress
GenomicsTarget genes of the MADS transcription factor SEPALLATA3, ChIP-seq
The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs, are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into o...
ORGANISM(S): Arabidopsis thaliana 
2009-04-20 | E-GEOD-14600 | biostudies-arrayexpress
TranscriptomicsProfiling of direct mRNA targets of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP
Micro RNAs (miRNAs) miR-130a, miR-203 and miR-205 are jointly downregulated in prostate cancer and act as repressors of AR-signaling. MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. Reconstitu...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-22979 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in LNCaP, PC3, Du-145 and RWPE-1 cell lines
MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. This series is meant to identify miRNAs deregulated in prostate cancer (PCa) by comparing the PCa cell lines LNCaP, PC3 and Du-145 to the normal ...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-17317 | biostudies-arrayexpress
TranscriptomicsmiRNA expression, mRNA expression upon miRNA reconstitution, and direct mRNA target identification in prostate cancer cell lines
This SuperSeries is composed of the following subset Series: GSE17315: mRNA expression upon reconstitution of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP GSE17317: miRNA expression in LNCaP, PC3, Du-145 and RWPE-1 cell lines GSE22979: Profiling of direct mRNA targets of miR-130a...
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-17362 | biostudies-arrayexpress
TranscriptomicsDeciphering the molecular immune response to COVID-19 using single cell multi-omics
Multi-omics single-cell profiling of surface proteins, gene expression and lymphocyte immune receptors from hospitalised COVID-19 patient peripheral blood immune cells and healthy controls donors. Identification of the coordinated immune cell compositional and state changes in response to SARS-CoV-2...
ORGANISM(S): Homo sapiens 
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
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