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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
MetabolomicsGenetic background shapes phenotypic response to diet for adiposity in the Collaborative Cross
Not available
ORGANISM(S): Mus musculus 
ST001607 | MetabolomicsWorkbench
Metabolomics3D'omics: Mannan fibre swine trial & Protein digestibility swine trial

Mannan fibre swine trial, BioProject PRJEB86261 at https://www.ebi.ac.uk/ena/browser/view/PRJEB86261

Protein digestibility swine trial, BioProject PRJEB86262 at https://www.ebi.ac.uk/ena/browser/view/PRJEB86262



2025-12-19 | MTBLS13348 | MetaboLights
MetabolomicsMonitoring recombinant protein expression in bacteria by rapid evaporative ionisation mass spectrometry

RATIONALE: There is increasing interest in methods of direct analysis mass spectrometry that bypass complex sample preparation steps.

METHODS: One of the most interesting new ionisation methods is rapid evaporative ionisation mass spectrometry (REIMS) in wh...

2022-01-28 | MTBLS957 | MetaboLights
MetabolomicsLipidomics study for investigating the role of the Unfolded Protein Response In Arabidopsis seed filling

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This lipidomic dataset was produced from Arabidopsis thaliana mature seeds. ...

2024-12-02 | MTBLS10597 | MetaboLights
Metabolomics1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats

BACKGROUND: Protein undernutrition is prevalent mainly among elderly people, and it could develop diseases such as sarcopenia. Urinary metabolites may become biomarkers reflecting protein undernutrition, but this has been insufficiently investigated.

OBJECTIVE:

2021-05-27 | MTBLS1452 | MetaboLights
MetabolomicsOverexpression of vesicle-associated membrane protein PttVAP27-17 as a tool to improve biomass production and the overall saccharification yields in Populus trees

Background

Bioconversion of wood into bioproducts and biofuels is hindered by the recalcitrance of woody raw material to bioprocesses such as enzymatic saccharification. Targeted modification of the chemical composition of the feedstock can improve saccharification but this gain is often abr...
2021-10-06 | MTBLS628 | MetaboLights
ProteomicsDecreasing Protein Biotinylation Background in a Diatom Facilitates Proximity Labeling of the Periplastidial Compartment Proteome
Diatoms are ecologically and industrially significant microalgae, crucial for global carbon fixation and biotechnological applications. Their complex plastid membrane structures, resulting from secondary endosymbiosis, remain poorly characterized, particularly the periplastidial compartment (PPC). P...
ORGANISM(S): Homo Sapiens Oryza Sativa Nicotiana Benthamiana Nannochloropsis Oceanica Thalassiosira Pseudonana Arabidopsis Thaliana Phaeodactylum Tricornutum 
2025-03-14 | PXD061818 |
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