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MetabolomicsThe timing of bacterial mesophyll infection shapes the leaf chemical landscape during the interaction

Chemistry in eukaryotic intercellular spaces is shaped by both hosts and symbiotic microorganisms such as bacteria. Pathogenic microorganisms like barley associated Xanthomonas translucens (Xt) swiftly overtake the inner leaf tissue becoming the dominant microbial community member during disease ...

2024-02-01 | MTBLS7676 | MetaboLights
MetabolomicsA gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection
The “gut-lung” axis is crucial for the chronic infection in bronchiectasis. However, the responsible microbe and the mechanism in the “gut-lung” axis of bronchiectasis are still in demand for precise elucidation. Here, we reported that Eggerthella lenta in the gut and taurine ursodeoxycholic acid (T...
2025-02-27 | MTBLS9522 | MetaboLights
MetabolomicsNMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

2020-11-19 | MTBLS563 | MetaboLights
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
MetabolomicsOriginal data of bacterial antibiotic resistance lipidomics
Plasmid-mediated dissemination of mcr genes has severely compromised colistin efficacy, necessitating adjuvants that restore antibacterial potency without exacerbating toxicity. Despite their essential roles in bacterial survival and virulence, metal ion acquisition systems remain underexplored as t...
2026-08-13 | MTBLS15318 | MetaboLights
MetabolomicsRice Infection Study
Not available
ORGANISM(S): Oryza sativa Japonica Group 
ST000007 | MetabolomicsWorkbench
MetabolomicsThe influence of Pseudomonas aeruginosa infection on the airway metabolome
Pseudomonas aeruginosa is an environmentally resilient bacterium and an important cause of both acute and chronic infections in people with impaired natural barriers or immunological defences. Chronic respiratory infection with P. aeruginosa is a major cause of morbidity and mortality in people with...
2025-11-06 | MTBLS6052 | MetaboLights
MetabolomicsSystematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes

Staphylococcus aureus is a major human pathogen responsible for severe infections. While traditionally described as extracellular, increasing evidence establishes S. aureus as a facultative intracellular pathogen. Intracellularity contributes to immune evasion, dissemination, and antibiotic failu...

2025-10-26 | MTBLS13220 | MetaboLights
MetabolomicsOverexpression of tlr5 adrffects gut microbiota resistance to Salmonella infection

BACKGROUND: The gut microbiome and the host immune system interact synergistically to maintain intestinal health and defend against infections. Toll-like receptor 5 (TLR5), known for recognizing bacterial flagellin, plays a pivotal role in this regulatory network. Despite significant advances in ...

2024-07-25 | MTBLS10592 | MetaboLights
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