In Gram negative bacteria outer membrane-associated lipoproteins caneither face the periplasm orprotrude out of the bacterial surface. The mechanisms involved in lipoprotein transport through the outer membrane are not fully elucidated. A group of lipoproteins reach the surface by using species-spec...
Localization of lipoproteins endogenously expressed under standard culture conditions was determined using multidimensional protein identification technology (MudPIT) mass spectrometry. B. burgdorferi B31A3 intact spirochetes were subjected to surface proteolysis with proteinase K.
We have used a lipoprotein-deficient mutant Streptococcus pneumoniae strain, delta lgt, to investigate the role of lipoproteins during inflammatory responses to live S. pneumoniae.
After co-evolving with humans, its only major host, Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication, yet elicits enough immunopathology to ensure its transmission. Here, we provide evidence that this balance is regulated in part by a previously uncharact...
