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MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
TranscriptomicsTranscription profiling of human HeLa cells treated with major listerial toxin listeriolysin
Upon infection, pathogens reprogram host gene expression. In eukaryotic cells, genetic reprogramming is induced by the concerted activation/repression of transcription factors and various histone modifications that control DNA accessibility in chromatin. We report here that the bacterial pathogen, ...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1078 | biostudies-arrayexpress
MetabolomicsBlocking Toxin function and Modulating Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments for Clostridioides difficile Infections

Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea that seriously threaten public health. Disruption of normal gut microbiota by the use of broad-spectrum antimicrobial agents enables C. difficile to proliferate in the colon. The emergence and prevalence o...

2024-06-04 | MTBLS9938 | MetaboLights
TranscriptomicsRNA-seq for identifying toxin MazF and MqsR cleavage sites in toxin expression and subsequent recovery cultures of Escherichia coli (mRNA and ncRNA excluding rRNA)
Bacterial toxin-antitoxin systems are thought to help bacteria to reduce their metabolism in various stressful conditions. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been mostly viewed as degraders of mRNA, however recently it was demonstrated that they ...
ORGANISM(S): Escherichia coli K-12 
2018-10-11 | E-MTAB-6993 | biostudies-arrayexpress
MetabolomicsMetabolomics profiling of full extracts of bacterial culture supernatants.
Not available
ORGANISM(S): Bacillus megaterium, Enterococcus faecium 
ST002306 | MetabolomicsWorkbench
TranscriptomicsReceptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
Bacillus thuringiensis israelensis (Bti) toxins are increasingly used for mosquito control, but little is known about the precise mode of action of each of these toxins, and how they interact to kill mosquito larvae. By using RNA sequencing, we investigated change in gene transcription level and pol...
ORGANISM(S): Aedes aegypti 
2019-05-16 | E-MTAB-7970 | biostudies-arrayexpress
MetabolomicsMetabolomics profiling of the secondary fractions 4 of bacterial culture supernatants.
Not available
ORGANISM(S): Bacillus megaterium, Enterococcus faecium 
ST002307 | MetabolomicsWorkbench
TranscriptomicsM. smegmatis vapBC::aphA-3 M-NM-^TvapBC mutant (JR121) harboring tetracycline inducible vector pMind containing the vapBC operon (pJR230) and the pMind vector containing the vapC toxin gene (pJR29)
Transcriptional profiling of M. smegmatis JR121 expressing VapC and VapBC grown in flasks on Hartmans de Bont medium supplemented with 0.2% glycerol Comparing transcriptional response of strain JR121 to conditional expression of VapC toxin compared with the expression of VapBC complex. Biological re...
ORGANISM(S): Mycobacterium smegmatis 
2012-06-14 | E-GEOD-29631 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
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