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TranscriptomicsDefining precision probes which differentiate between the activity of type I and type II interferons.
To define probes which differentiate between the activity of type I or type II IFN, a human submandibular gland (HSG) cell line was cultured for 48 hours in the absence or presence of IFNa or IFNg. Gene expression was assayed at 4, 12, 24 or 48 hours and was compared to gene expression in untreated ...
ORGANISM(S): Homo sapiens 
2012-10-08 | E-GEOD-41291 | biostudies-arrayexpress
GenomicsBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-35698 | biostudies-arrayexpress
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