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TranscriptomicsGene expression profiling of ovaries collected from mice treated with or without Ulipristal
Ulipristal acetate (UPA), also referred to as VA/CDB-2914, is a new and promising emergency contraceptive. It is a selective progesterone receptor modulator (SPRM) that has been approved in Europe and the USA for emergency contraception. To experimentally induce ovulation, the immature CD-1 mice (24...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-37353 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ovaries collected from wild type (WT) mice and progesterone receptor (PR) knock out mice
Previous studies have shown that PR is a critical regulator of ovulation. The PR-null mice (PRKO) failed to ovulate due to a failure in the rupture of the preovulatory follicles. To experimentally induce ovulation, the wild type and PR null mice (C57BL/6, 24–28 d old) were injected ip with 5 IU of P...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-37354 | biostudies-arrayexpress
GenomicsGenome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells
We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, k...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-GEOD-62475 | biostudies-arrayexpress
TranscriptomicsExpression data of PGR isoforms, PRA and PRB, regulated genes in differentiating human endometrial stromal cells
gene expression at 6h of differentiation of Human endometrial stromal cell expressing either or both of PRA and PRB Endogenous PGR expression is silenced with siRNA mediated knockdown. Then, cells are transduced with adenovirus exressing flag tagged PRA or flag tagged PRB. Human endometrial stromal ...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-GEOD-48853 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of uterine stromal cells isolated from Hand2 floxed and Hand2 ablated mice on day 4 of pregnancy
Our previous study revealed that the basic helix-loop-helix transcription factor Hand2 is a downstream target of progesterone signaling in mouse uterine stroma at the time of implantation. Further, conditional deletion of Hand2 in mouse uterus leads to implantation failure due to impaired uterine ep...
ORGANISM(S): Mus musculus 
2011-06-03 | E-GEOD-25881 | biostudies-arrayexpress
TranscriptomicsTob1 is a Constitutively Expressed Repressor of Liver Regeneration
How proliferative and inhibitory cell signals integrate to control liver regeneration remains poorly understood. A screen for antiproliferative factors repressed after liver injury identified Tob1, a member of the PC3/BTG1 family of mitoinhibitory molecules as a target for further evaluation. Tob1...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21836 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human endometrial stromal cells transduced with BMP2- and WNT4-adenovirus.
Our previous studies have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFM-NM-2 superfamily, is markedly induced in human primary endometrial stromal cells (HESC) as they undergo differentiation in response to steroid hormones and cAMP. WNT4 is a downstream target of...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-39949 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of uterine stromal cells isolated from Msx1Msx2 floxed and Msx1Msx2 ablated mice on day 4 of pregnancy
Our preliminary study revealed that the homeobox transcription factors, Msx1 and Msx2, are expressed in the mouse uterus during early pregnancy. Further, conditional deletion of Msx1 and Msx2 in mouse uterus leads to implantation failure due to impaired uterine epithelial receptivity. To identify th...
ORGANISM(S): Mus musculus 
2014-07-20 | E-GEOD-30966 | biostudies-arrayexpress
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