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TranscriptomicsGene expression profiling of uterine stromal cells isolated from Hand2 floxed and Hand2 ablated mice on day 4 of pregnancy
Our previous study revealed that the basic helix-loop-helix transcription factor Hand2 is a downstream target of progesterone signaling in mouse uterine stroma at the time of implantation. Further, conditional deletion of Hand2 in mouse uterus leads to implantation failure due to impaired uterine ep...
ORGANISM(S): Mus musculus 
2011-06-03 | E-GEOD-25881 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ovaries collected from mice treated with or without Ulipristal
Ulipristal acetate (UPA), also referred to as VA/CDB-2914, is a new and promising emergency contraceptive. It is a selective progesterone receptor modulator (SPRM) that has been approved in Europe and the USA for emergency contraception. To experimentally induce ovulation, the immature CD-1 mice (24...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-37353 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ovaries collected from wild type (WT) mice and progesterone receptor (PR) knock out mice
Previous studies have shown that PR is a critical regulator of ovulation. The PR-null mice (PRKO) failed to ovulate due to a failure in the rupture of the preovulatory follicles. To experimentally induce ovulation, the wild type and PR null mice (C57BL/6, 24–28 d old) were injected ip with 5 IU of P...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-37354 | biostudies-arrayexpress
GenomicsGenome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells
We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, k...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-GEOD-62475 | biostudies-arrayexpress
TranscriptomicsGene expression profile of epithelial ovarian tumor tissue of a transgenic mouse model compared to normal mouse ovary tissue
The etiology of ovarian cancer is poorly understood, mainly due to the lack of an appropriate experimental model for studying the onset and progression of this disease. We have created a mouse model termed ERalpha d/d in which a conditional deletion of estrogen receptor alpha (ERalpha) gene occurred...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-39402 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse uterine epithelial cells isolated on morning of day 4 of pregnancy
Embryo implantation into a receptive endometrium is tightly regulated by a variety of maternal factors, including cytokines, growth factors and transcription factors. Previous studies identified the leukaemia inhibitory factor (LIF), produced in uterine glands, as an essential factor for implantatio...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-44087 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of C/EBPM-NM-2- and STAT3-deficient human endometrial stromal cells (HESC)
Our previous studies have shown that C/EBPM-NM-2 plays a critical role in human endometrial stromal decidualization. In order to identify the molecular pathways regulated by C/EBPM-NM-2 during decidualization, we performed gene expression profiling using RNA isolated from normal and C/EBPM-NM-2-defi...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-41473 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of uterine stromal cells isolated from Msx1Msx2 floxed and Msx1Msx2 ablated mice on day 4 of pregnancy
Our preliminary study revealed that the homeobox transcription factors, Msx1 and Msx2, are expressed in the mouse uterus during early pregnancy. Further, conditional deletion of Msx1 and Msx2 in mouse uterus leads to implantation failure due to impaired uterine epithelial receptivity. To identify th...
ORGANISM(S): Mus musculus 
2014-07-20 | E-GEOD-30966 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of uterine epithelial cells isolated from Msx1Msx2 floxed and Msx1Msx2 ablated mice on day 4 of pregnancy
Our preliminary study revealed that the homeobox transcription factors, Msx1 and Msx2, are expressed in the mouse uterus during early pregnancy. Further, conditional deletion of Msx1 and Msx2 in mouse uterus leads to implantation failure due to impaired uterine epithelial receptivity. To identify th...
ORGANISM(S): Mus musculus 
2014-07-20 | E-GEOD-30968 | biostudies-arrayexpress
UnknownMultidisciplinary management of persistent severe cancer pain: a collaborative European approach.
Not available
S-EPMC12578720 | biostudies-literature
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