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UnknownEffects of marketed antiepileptic drugs and placebo in the human photosensitivity screening protocol.
A study of epilepsy patients with a reproducible range of photoparoxysmal responses (PPR) (epileptiform discharges evoked by flashing lights) has been used as a "proof-of-concept" trial to determine if novel potential antiepileptic drugs (AEDs) should proceed in development. The standard design for ...
S-EPMC3996112 | biostudies-literature
UnknownImpact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial.

Objective

Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for the treatment of depression and anhedonia, a reduced ability to experience pleasure. The authors conducted the first randomized placebo-controlled trial testing the effect of the KCNQ2/3 positive modul...
S-EPMC8791195 | biostudies-literature
UnknownEffectiveness of radiation therapy for elderly patients with unresected stage I and II non-small cell lung cancer.

Rationale

Radiotherapy (RT) is considered the standard treatment for patients with stage I or II non-small lung cancer who are not surgical candidates because of comorbities or preferences against surgery.

Objectives

To compare the outcomes of patients treated with RT alone with those...
S-EPMC2817815 | biostudies-literature
UnknownSex-based Differences and Comparative Predictive Value of MELD 3.0 in Simultaneous Liver-Kidney Transplantation Waitlist Outcomes After Standardization of Listing Criteria in the United States
Not available
S-EPMC11984772 | biostudies-literature
UnknownTime to prerandomization monthly seizure count in perampanel trials: A novel epilepsy endpoint.

Objective

To determine whether a novel endpoint of time to prerandomization monthly seizure count could be used to differentiate efficacious and nonefficacious therapies in clinical trials of new add-on antiepileptic drugs (AEDs).

Methods

This analysis used data from 3 randomized, dou...
S-EPMC4442101 | biostudies-literature
UnknownFactors associated with placebo response rate in randomized controlled trials of antiseizure medications for focal epilepsy.

Objective

Randomized controlled trials (RCTs) are necessary to evaluate the efficacy of novel treatments for epilepsy. However, there have been concerning increases in the placebo responder rate over time. To understand these trends, we evaluated features associated with increased placebo re...
S-EPMC11827720 | biostudies-literature
UnknownSwallowed Fluticasone Propionate Is an Effective Long-Term Maintenance Therapy for Children With Eosinophilic Esophagitis.

Objectives

Although effective in the treatment of eosinophilic esophagitis (EoE) in children, limited data exist on long-term safety and efficacy of swallowed topical corticosteroids. We investigated whether long-term use of swallowed fluticasone in children with EoE leads to sustained reduc...
S-EPMC5557271 | biostudies-literature
UnknownHigh Levels of Psychological Resilience Are Associated With Decreased Anxiety in Inflammatory Bowel Disease.

Background

Anxiety and depression are comorbid disorders with IBD and are associated with poor outcomes. Resilience is an innate but modifiable trait that may improve the symptoms of psychological disorders. Increasing resilience may decrease the severity of these comorbid disorders, which m...
S-EPMC9165553 | biostudies-literature
UnknownBehavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury.
The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction. The aim of this observational cohort study was to systemat...
S-EPMC6964809 | biostudies-literature
UnknownFertility and Birth Outcomes in Women With Epilepsy Seeking Pregnancy.

Importance

Prior studies report lower birth rates for women with epilepsy (WWE) but have been unable to differentiate between biological and social contributions. To our knowledge, we do not have data to inform WWE seeking pregnancy if their likelihood of achieving pregnancy is biologically ...
S-EPMC6142930 | biostudies-literature
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