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MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
TranscriptomicsSelective mRNA sequestration by OLIGOURIDYLATE BINDING PROTEIN 1 contributes to translational control during hypoxia in Arabidopsis
Low oxygen stress dynamically regulates the translation of cellular mRNAs as a means of energy conservation in seedlings of Arabidopsis thaliana. Most of the highly hypoxia-induced mRNAs are recruited to polysomes and actively translated, whereas other cellular mRNAs become translationally inactive ...
ORGANISM(S): Arabidopsis thaliana 
2014-01-13 | E-GEOD-49411 | biostudies-arrayexpress
TranscriptomicsArabidopsis cold regulated transcriptome, translatome and CSP1 RNA regulon
Transcriptome, translatome, and CSP1 RNA regulon analysis of 25-d-o Arabidopsis rosettes exposed to 12h low temperature (4C) treatment. 38 samples, 3 genotypes (35S:HF-RPL18, 35S:AtCSP1-FH#11, and atcsp1-1), 2 conditions (non-stress and cold), 3 RNA pools (total, polysomal, and CSP1 associated mRNAs...
ORGANISM(S): Arabidopsis thaliana 
2013-03-31 | E-GEOD-38030 | biostudies-arrayexpress
UnknownMineral micronutrient status and spatial distribution among the Ethiopian population.
Not available
S-EPMC9661372 | biostudies-literature
TranscriptomicsMicroarray data from pre-germinated seeds and hypoxia-treated seedlings of Arabidopsis prt6-1 and ate1 ate2 mutants of the N-end rule pathway of targeted proteolysis pathway
This study analyzes transcriptome profiles in pre-germinated seeds and hypoxia-treated seedlings of Arabidopsis thaliana wild type (Col-0) and homozygous mutants (prt6-1 and ate1 ate2). This dataset includes CEL files, RMA signal values and MAS5 P/M/A calls. For pre-germinated seeds, seeds imbibed f...
ORGANISM(S): Arabidopsis thaliana 
2011-10-22 | E-GEOD-29941 | biostudies-arrayexpress
TranscriptomicsBrucella melitensis-infected HeLa cells gene expression
In a time course study, we characterized global gene expression profile of B. melitensis-infected epithelium-like cells at the onset of infection. B. melitensis-infected HeLa cells exhibited a down-regulated expression profile at 4 h (48 up- and 109 down-regulated genes) that transitioned to an acti...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-14703 | biostudies-arrayexpress
MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
UnknownMyalgic Encephalomyelitis-Chronic Fatigue Syndrome Common Data Element item content analysis.
Not available
S-EPMC10497138 | biostudies-literature
TranscriptomicsEffect of ablation of Max gene expression on ES cells cultured under conventional or 2i/Nam condition.
c-Myc is one of key players that are crucially involved in maintaining the undifferentiated state and the self-renewal of ESCs. To understand the mechanism by which c-Myc helps preserve these prominent characteristics of ESCs, we generated null-ES cells for the Max gene, which encodes the best chara...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-27881 | biostudies-arrayexpress
UnknownComparator Data Characteristics and Testing Procedures for the Clinical Performance Evaluation of Continuous Glucose Monitoring Systems.
Not available
S-EPMC10979680 | biostudies-literature
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