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Das2010 - Effect of a gamma-secretase inhibitor on Amyloid-beta dynamics This model is described in the article: Modeling effect of a ?-secretase inhibitor on amyloid-? dynamics reveals significant role of an amyloid clearance mechanism. Das R, Nachbar RB, Edelstein-Keshet L...
2024-09-02 | BIOMD0000000551 | BioModels
NaM-CM-/ve, liver- and gut-activated CD8 OT-I T cells show differential migration behaviour. To analyze which genes could be responsible for different migration patterns, naM-CM-/ve, liver-activated and gut-activated CD8 T cells were isolated and compared for their gene expression profile. Gene expr...
ORGANISM(S): Mus musculus 
An observational experiment to RNA-seq profile 331 primary tumours from patients diagnosed with Medulloblastoma.
ORGANISM(S): Homo sapiens 
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive d...
ORGANISM(S): Mus musculus 
MRT cell lines KD, SWOH, LM, DEV and G401 were expression profiled following SMARCB1 re-expression using a lentivirus. Samples were taken at Day 0,1,3,7 and 14 and compared to empty vector control experiments.
ORGANISM(S): Homo sapiens 
An observational experiment to methylation profile 79 SMARCB1 negative primary tumours from patients diagnosed with Malignant Rhabdoid Tumours.
ORGANISM(S): Homo sapiens 
NaM-CM-/ve mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping, we show that a small fraction of transcripts are differentially expressed between mESCs and mEpiSCs...
ORGANISM(S): Mus musculus 
STAT1 is the major transcription factor (TF) driving response to exposure to IFNg. C-JUN is a TF which has been shown to bind with STAT1 and act as a partner TF. We have expression profiled WT and CJUN-/- MEFs in order to determine the set of IFNg genes regulated by STAT1 and C-JUN. This study was d...
ORGANISM(S): Mus musculus 
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