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GenomicsDerivation of novel human ground state naM-CM-/ve pluripotent stem cells
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling ...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-52617 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium exposure to triclosan
S. Typhimurium SL1344 was exposed to the minimum inhibitory concentration of triclosan and the transcriptomic response analysed.
ORGANISM(S): Salmonella enterica 
2009-08-28 | E-MEXP-2078 | biostudies-arrayexpress
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
TranscriptomicsMll2 is required for H3K4 trimethylation on bivalent promoters in ES cells whereas Mll1 is redundant
Trimethylation of histone 3 lysine 4 (H3K4me3) at promoters of actively transcribed genes is a universal epigenetic mark and a key product of Trithorax-Group action. Here we show that Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bival...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-52071 | biostudies-arrayexpress
UnknownStructure and Function of Viral Deubiquitinating Enzymes.
Not available
S-EPMC7094624 | biostudies-literature
UnknownIndependent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein.
Not available
S-EPMC7271988 | biostudies-literature
UnknownViral OTU deubiquitinases: a structural and functional comparison.
Not available
S-EPMC3968130 | biostudies-literature
UnknownVariability in age and size at maturation, reproductive longevity, and long-term growth dynamics for Kemp's ridley sea turtles in the Gulf of Mexico.
Not available
S-EPMC5363829 | biostudies-literature
UnknownCisMapper: predicting regulatory interactions from transcription factor ChIP-seq data.
Not available
S-EPMC5389714 | biostudies-literature
TranscriptomicsDerivation of novel human ground state naM-CM-/ve pluripotent stem cells
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3b signalling ...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-46872 | biostudies-arrayexpress
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