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TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
TranscriptomicsNuclear factor kappa B activation-induced anti-apoptosis renders HER2 positive cells drug resistant and accelerates tumor growth
Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2- positive breast cancer, but resistance inevitably occurs. We previously found that nuclear factor kappa B is hyper-activated in the...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-52707 | biostudies-arrayexpress
UnknownMONARCC: a randomised phase II study of panitumumab monotherapy and panitumumab plus 5-fluorouracil as first-line therapy for RAS and BRAF wildtype metastatic colorectal cancer: a study by the Australasian Gastrointestinal Trials Group (AGITG).
Not available
S-EPMC8371602 | biostudies-literature
UnknownProteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury.
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S-EPMC8260874 | biostudies-literature
UnknownSystematic Analysis of Splice-Site-Creating Mutations in Cancer.
Not available
S-EPMC6055527 | biostudies-literature
UnknownDriver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Not available
S-EPMC5916809 | biostudies-literature
UnknownPerspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
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S-EPMC5916814 | biostudies-literature
UnknownPathogenic Germline Variants in 10,389 Adult Cancers.
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S-EPMC5949147 | biostudies-literature
UnknownComprehensive Characterization of Cancer Driver Genes and Mutations.
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S-EPMC6029450 | biostudies-literature
UnknownThe National Lung Screening Trial: overview and study design.
Not available
S-EPMC3009383 | biostudies-literature
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