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TranscriptomicsExpression profiles from a variety of resting and activated human immune cells
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood an...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-22886 | biostudies-arrayexpress
TranscriptomicsWhole Blood Transcriptional Modules generated on Illumina Hu-6 V2 Beadchips
This dataset was used to establish whole blood transcriptional modules (n=260) that represent groups of coordinately expressed transcripts that exhibit altered abundance within individual datasets or across multiple datasets. This modular framework was generated to reduce the dimensionality of whol...
ORGANISM(S): Homo sapiens 
2014-03-11 | E-GEOD-29536 | biostudies-arrayexpress
TranscriptomicsIFNa DCs and IL4 DCs exposed to H1N1, heat killed S. aureus, or heat killed S. enterica (HKSE) for 1h, 2h, 6h, 12h, or 24h
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44720 | biostudies-arrayexpress
TranscriptomicsIFNa and IL4 DCs stimulated with microbial components for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44719 | biostudies-arrayexpress
TranscriptomicsIL4 DCs and monocytes stimulated by 13 human vaccines and LPS for 6hr
While dendritic cells (DCs) are known to play a major role in the process of vaccination, the mechanisms by which vaccines induce protective immunity in humans remain elusive. Herein, we used gene microarrays to characterize the transcriptional programs induced over time in human monocyte-derived DC...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44721 | biostudies-arrayexpress
UnknownPrenatal Intravenous Magnesium at 30-34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring: The MAGENTA Randomized Clinical Trial.
Not available
S-EPMC10427942 | biostudies-literature
TranscriptomicsBDCA1+ mDCs and BDCA3+ mDCs stimulated with vaccines for 6 hr
The mechanisms by which vaccines interact with human APCs remain elusive. We applied systems biology to define the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Upon exposing DCs to influenza, Salmonella enterica and Staphylococcus aureus, we built...
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-56744 | biostudies-arrayexpress
TranscriptomicsTranscriptional specialization of human dendritic cell subsets in response to microbial vaccines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-44722 | biostudies-arrayexpress
UnknownMulti-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
Not available
S-EPMC12273372 | biostudies-literature
UnknownEvaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection.
Not available
S-EPMC5853450 | biostudies-literature
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